3-Fluorophenylboronic acid
We are a manufacturer based in China, specializing in high-quality 3-Fluorophenylboronic acid for industrial clients worldwide. Technical support and custom formulation available.
Category：Chemical Intermediates | Brand：MT
Introduction
3-Fluorophenylboronic acid is an organoboron compound with a fluorine substituent on the phenyl ring and a boronic acid group. This compound is widely used in organic synthesis and material science due to its unique reactivity and structural properties.
Key Properties
| Property | Details |
|---|---|
| IUPAC Name | 3-Fluorophenylboronic acid |
| CAS Number | 768-35-4 |
| Molecular Formula | C₆H₆BFO₂ |
| Molecular Weight | 139.92 g/mol |
| Appearance | White to light yellow crystalline powder |
| Boiling Point | ~271.4°C |
| Melting Point | 214-218°C |
| Density | ~1.24 g/cm³ |
| Acidity (pKa) | 7.50±0.10 (predicted) |
| Solubility | Soluble in methanol |
| Synthesis Method | Grignard reagent reaction with trimethyl borate |
| Applications | Organic synthesis, medicinal chemistry, development of novel pharmaceuticals |
Synthesis
3-Fluorophenylboronic acid can be synthesized via a Grignard reagent reaction. The process involves reacting 3-fluorobromobenzene with magnesium turnings in 2-methyltetrahydrofuran under nitrogen atmosphere to generate the Grignard reagent, which is then reacted with trimethyl borate. After hydrolysis and recrystallization, 3-Fluorophenylboronic acid is obtained.
Applications
In organic synthesis, 3-Fluorophenylboronic acid serves as a valuable building block for the preparation of complex molecules, particularly those requiring defined stereochemistry and functionality. The fluorophenylboronic acid moiety makes it a promising candidate for the development of novel pharmaceuticals, agrochemicals, and functional materials. The boronic acid group can be further transformed into other functional groups, expanding the scope of its applications.
Inquiry
We'll reply within 24 hours
