3-Fluoro-2-Methoxybenzoic Acid CAS No.106428-05-1
Category：Pharmaceutical Materials
Introduction
Names and Identifiers
| Name | 3-FLUORO-2-METHOXYBENZOIC ACID |
| Synonyms | 3-FLUORO-2-METHOXYBENZOIC ACID Benzoic acid, 3-fluoro-2-methoxy- |
| CAS | 106428-05-1 |
| InChI | InChI=1/C8H7FO3/c1-12-7-5(8(10)11)3-2-4-6(7)9/h2-4H,1H3.(H,10.11) |
Physico-chemical Properties
| Molecular Formula | C8H7FO3 |
| Molar Mass | 170.14 |
| Density | 1.307 |
| Melting Point | 112-114°C |
| Boling Point | 288℃ |
| Flash Point | 128℃ |
| Vapor Presure | 0.00111mmHg at 25°C |
| pKa | 3.75±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.524 |
| MDL | MFCD00973972 |
Risk and Safety
| Risk Codes | 22 – Harmful if swallowed |
| Hazard Note | Irritant |
Introduction
3-fluoro-2-methoxybenzoic acid, chemical formula C8H7FO3. is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
- -Appearance: 3-fluoro-2-methoxybenzoic acid is a colorless crystalline solid.
- -Solubility: It is soluble in most organic solvents, such as ether, dichloromethane, etc.
- -Melting point: The compound melts in the range of about 120-125°C.
- -Stability: It is relatively stable to light and heat.
Use:
3-fluoro-2-methoxybenzoic acid has certain applications in the field of pharmaceutical synthesis and pesticide manufacturing. It can be used as an intermediate in the synthesis of some drugs and pesticides, such as anti-epileptic drugs (such as pyrrolidine) and pesticides.
Preparation Method:
A common preparation method is to prepare 3-fluoro-2-methoxybenzoic acid through the fluorination reaction of 2-methoxybenzoic acid. Specifically, the target product can be obtained by reacting 2-methoxybenzoic acid with hydrogen fluoride in the presence of a strong acid such as hydrofluoric acid.
Safety Information:
- -3-Fluoro-2-methoxybenzoic acid is an organic compound. When using it, pay attention to protective measures to avoid direct contact with skin, eyes or inhalation of its vapor.
- -It may have a stimulating effect on the human body, so long-term exposure should be avoided.
- -When using or storing, keep away from fire and high temperature environment, and keep a well-ventilated place for operation.
- -If taken by mistake or inhaled, seek medical attention immediately. If skin or eye contact occurs, rinse with plenty of water and seek medical help.
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