Pharmaceutical Materials

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (CAS No.: 176969-34-9), also known as biflupyrazole acid, is a crucial organic intermediate widely utilized in pharmaceutical and agrochemical industries. As a key precursor, it plays a vital role in synthesizing pyrazole-based fungicides, such as bixafen and fluopyram, which exhibit excellent activity against various plant pathogens. The compound is typically synthesized via a reaction involving 3-bromodifluoromethyl-1-methyl-1H-pyrazole and carbon dioxide, followed by hydrolysis. Its white to off-white crystalline solid form, combined with properties such as a melting point of 201-203°C and a boiling point of 315.9 ± 42.0°C, makes it suitable for diverse chemical applications. Research highlights its potential in developing new bioactive compounds with enhanced efficacy and environmental compatibility.

Usage: 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid used as a pharmaceutical intermediate.

Packaging and Shipping：25kg/drum or as per buyer’s requirements.

Storage: Storage in ventilated low temperature dry warehouse; Keep container closed and separately from open flame and heat source.

Name	3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Synonyms	Fluxypyroxad Metabolite M700F001 FLUXYPYROXAD METABOLITE M700F001 4-Carboxy-3-difluoromethyl-1-methyl pyrazole 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxyl 3-(difluoromethyl)-1-methylpyrazole-4-carboxylicaci 3-Difluoromethyl-1-methylpyrazole-4-carboxylic acid 3-Difluoromethyl-1-methyl-1H-pyrazol-4-carboxylic acid 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid 1-methyl-3-(difluoromethyl)-1H-pyrazole-4-carboxylic acid 1H-Pyrazole-4-carboxylicacid, 3-(difluoroMethyl)-1-Methyl-
CAS	176969-34-9
InChI	InChI=1/C6H6F2N2O2/c1-10-2-3(6(11)12)4(9-10)5(7)8/h2,5H,1H3,(H,11,12)

176969-34-9 – Physico-chemical Properties

Molecular Formula	C6H6F2N2O2
Molar Mass	176.12
Density	1.52
Melting Point	201-203°C
Boling Point	315.9±42.0 °C(Predicted)
Flash Point	144.9°C
Solubility	DMSO (Slightly), Methanol (Sparingly)
Vapor Presure	0-0.397Pa at 20-99.7℃
Appearance	Solid
Color	White to Off-White
pKa	3.12±0.36(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.533

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