3-Chloropropyne
Agrochemicals 2025-03-02
3-Chloropropyne (Propargyl Chloride, CAS No. 624-65-7)
1. Basic Information
- IUPAC Name: 3-Chloroprop-1-yne
- Synonyms:
- Propargyl chloride
- Chloromethylacetylene
- CAS Number: 624-65-7
- Molecular Formula: C₃H₃Cl
- Molecular Weight: 74.51 g/mol
- Appearance: Colorless to pale yellow liquid
- Odor: Pungent, garlic-like odor
2. Physical and Chemical Properties
| Property | Value |
|---|---|
| Boiling Point | 57–59°C (135–138°F) |
| Density | 1.03 g/cm³ (20°C) |
| Refractive Index | 1.432 (20°C) |
| Flash Point | -20°C (-4°F) (closed cup) |
| Solubility | – Water: Slightly soluble |
| – Organic solvents: Miscible with ethanol, ether, acetone | |
| Vapor Pressure | 200 mmHg at 20°C |
3. Chemical Structure
Cl
|
CH≡C-CH₃
4. Hazards (GHS Classification)
- Flammability: Highly flammable liquid (H224)
- Health Hazards:
- Fatal if inhaled (H330)
- Causes severe skin burns (H314)
- Causes serious eye damage (H318)
- Environmental: Toxic to aquatic life (H411)
- NFPA Rating: Health 3, Flammability 3, Reactivity 2
5. Storage and Handling
- Storage:
- Store in explosion-proof refrigerators (<10°C) under inert gas (N₂)
- Keep away from heat/sparks/open flames
- Handling:
- Use explosion-proof equipment and chemical-resistant gloves (Viton®/butyl rubber)
- Work in a fume hood with <25% lower explosive limit (LEL) monitoring
6. Applications
- Organic Synthesis:
- Alkynylation agent for C-C bond formation
- Intermediate for pharmaceuticals (e.g., HIV protease inhibitors)
- Polymer Industry:
- Crosslinking agent for specialty resins
- Agrochemicals:
- Building block for fungicides
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