3-Chloroaniline CAS No.108-42-9

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Introduction

3-Chloroaniline (CAS No. 108-42-9) 

1. Basic Information

  • Chemical Name: 3-Chloroaniline
  • Synonyms: m-Chloroaniline; 3-Chlorobenzenamine; 1-Amino-3-chlorobenzene
  • CAS Number: 108-42-9
  • Molecular Formula: C₆H₆ClN
  • Molecular Weight: 127.57 g/mol
  • Appearance: Colorless to pale yellow liquid (turns brown on exposure to air/light)
  • Odor: Amine-like (fishy) odor
  • Odor Threshold: ~0.1 ppm

2. Physical and Chemical Properties

  • Melting Point: -10°C (14°F)
  • Boiling Point: 230-231°C (446-448°F)
  • Density: 1.216 g/cm³ at 20°C
  • Solubility:
    • Water: 5 g/L (20°C)
    • Organic solvents: Miscible with ethanol, ether, acetone
  • Vapor Pressure: 0.03 mmHg at 20°C
  • Flash Point: 97°C (207°F) (closed cup)
  • Refractive Index: 1.593 at 20°C

3. Hazards (GHS Classification)

  • Acute Toxicity: Toxic if swallowed/inhaled (H301+H311+H331)
  • Skin Corrosion/Irritation: Causes skin irritation (H315)
  • Serious Eye Damage: Causes eye irritation (H319)
  • Sensitization: May cause skin allergy (H317)
  • Environmental Hazards: Toxic to aquatic life (H411)
  • NFPA Rating: Health 3, Flammability 1, Reactivity 0

4. Storage and Handling

  • Storage:
    • Amber glass bottles under inert gas (N₂)
    • Store at 2-8°C protected from light
  • Handling:
    • PPE: Nitrile gloves, vapor respirator, chemical goggles
    • Work in fume hood with <50 ppm exposure control

5. Applications

  • Dye Intermediate: Production of azo dyes and pigments
  • Pharmaceuticals: Precursor for sulfa drugs
  • Agrochemicals: Synthesis of herbicides/pesticides

Disclaimer:

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