Pharmaceutical Materials

Product Name

3-Chloro-4-Methylaniline

3-Multiple Names

Chloro-4-Methylaniline;

4-Chloro-P-Toluidine (NH2=1);

2-Chloro-4-Aminotoluene;

3-Amino-2-Chlorotoluene;

4-Chloro-p-Toluidine;

2B Oil

CAS No. 95-74-9

EC No. 202-446-3

MF No. C7H8ClN

MW No. 141.6

3-Chloro-4-methylaniline is the intermediate of the herbicide chlorotoluron. Organic synthesis intermediates, used in the production of organic pigment intermediate 2B acid and pesticide chlorsulfuron, used in the production of organic pigment intermediate 2B acid and pesticide chlorsulfuron herbicide and pharmaceutical intermediates.

Advantage of 3-Chloro-4-Methylaniline CAS No. 95-74-9

Stable, combustible, incompatible with strong oxidizing agents

Good growth promotion

It can also be reduced with sodium sulfide

Names and Identifiers

Name	3-Chloro-4-methylaniline
Synonyms	CPT 3-cpt 2B oil AKOS BBS-00003549 3-Chloro-p-toluidine 3-CHLORO-P-TOLUIDINE 3-amino-2-chlorotoluene 4-Amino-2-chlorotoluene 2-chloro-4-aminotoluene 4-AMINO-2-CHLOROTOLUENE 3-Chloro-4-methylaniline 3-CHLORO-4-METHYLANILINE 3-chloro-4-methyl-benzenamine
CAS	95-74-9
EINECS	202-446-3
InChI	InChI=1/C7H8ClN/c1-5-2-3-6(9)4-7(5)8/h2-4H,9H2,1H3

95-74-9 – Physico-chemical Properties

Molecular Formula	C7H8ClN
Molar Mass	141.6
Density	1.17
Melting Point	25 °C
Boling Point	237-238°C(lit.)
Flash Point	212°F
Water Solubility	1 g/L (20 ºC)
Vapor Presure	4.973-8.666Pa at 25℃
Appearance	Oillike solid
Specific Gravity	1.167
Color	White or Colorless to Light orange to Yellow
BRN	636511
pKa	pK1: 4.05(+1) (25°C)
Storage Condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acids, acid anhydrides, chloroformates, reducing agents.
Sensitive	Sensitive to light
Refractive Index	n20/D 1.584(lit.)
MDL	MFCD00007773
Physical and Chemical Properties	This product is an oily solid at room temperature, m.p.26 ℃, B. p.237 ~ 238 ℃,n20D 1.5840, relative density 1.167,f.p.212 ℉(100 ℃), soluble in benzene, alcohol, ether and other solvents.
Use	For the manufacture of organic pigment intermediate 2B acid and pesticide green Malone herbicide and pharmaceutical intermediates

95-74-9 – Risk and Safety

Risk Codes	R24/25 – R36/38 – Irritating to eyes and skin. R43 – May cause sensitization by skin contact R50/53 – Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36/37/38 – Irritating to eyes, respiratory system and skin. R22 – Harmful if swallowed
Safety Description	S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 – Avoid release to the environment. Refer to special instructions / safety data sheets. S60 – This material and its container must be disposed of as hazardous waste. S36/37 – Wear suitable protective clothing and gloves. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs	UN 2239 6.1/PG 3
WGK Germany	2
RTECS	XU5111000
TSCA	Yes
HS Code	29214300
Hazard Class	6.1
Packing Group	III

95-74-9 – Reference Information

LogP	2.27
Use	3-chloro-4-methylaniline is an intermediate of the herbicide chloroburon. organic synthesis intermediate, used in the production of organic pigment intermediate 2B acid and pesticide green Malone. used in the manufacture of organic pigment intermediate 2B acid and pesticide green Malone herbicide and pharmaceutical intermediates, etc.
production method	p-nitrotoluene is obtained by chlorination and reduction. 1. Chlorination the nitrotoluene is added to the reaction Pan, heated to 75 ℃, and added with anhydrous ferric chloride and iodine. After stirring for 10-20min, the chlorine is started at 60 ℃, and the chlorination temperature is maintained at 55-70 ℃, when the chloride melting point> 58.5 C in 20min does not grow so far. The temperature was increased to 80-90 ° C. And maintained at 1.5-2H to obtain 2-chloro-4-nitrotoluene with a yield of 98%. 2. The prepared sodium sulfide solution was added into the reaction pot, and the above 2-chloro-4-nitrotoluene was added at 70-80 ℃, and refluxed for 4H at 110±5 ℃, with the purity of amine Oil> 98.5%, when the melting point was> 19 °c, the product was obtained by distillation with a yield of 90%. If iron powder is used for reduction and the reaction temperature is about 100 ° C., the reactant is extracted with toluene. The yield was about 95%. The preparation method is to add the molten 3-chloro-4-methylnitrobenzene and the solvent into the autoclave, and then draw the quantitative catalyst and distilled water into the autoclave under negative pressure, the catalytic hydrogenation reaction is carried out at a certain temperature and pressure, and then the material is pumped into the storage tank, left to stand and layered, and the material is rectified in the distillation kettle to obtain the solvent and the finished product respectively. Can also be reduced with sodium sulfide, sodium sulfide is added to the reaction pot, 3-chloro-4-methylnitrobenzene was added at 70-80 °c and refluxed for 4H at (110±5) °c. After completion of the reaction, the layers were separated and distilled to obtain a finished product.

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