3-Chloro-2-methylaniline
Pharmaceutical Materials 2025-03-02
Production method Obtained from o-nitrotoluene by chlorination and reduction.1.ChlorinationIn o-nitrotoluene, add 2% of ferric trichloride as a catalyst, pass chlorine at 50-60 ℃, until the relative density of the reaction liquid reaches 1.27-1.29 (50 ℃), wash with 5% hydrochloric acid, then wash with water, and finally adjust the pH with liquid alkali as 7. Separate out the aqueous layer, after evaporating the water, and then carry out decompression distillation to collect the fraction of 120-150 ℃ (5.33-8.0kPa). 120-150 ℃ (5.33-8.0kPa) fraction, cooling crystallization, filtration, to get 2-chloro-6-nitrotoluene.2. Reduction of hydrochloric acid and iron powder added to the reaction pot stirring and heating to 90 ℃, slowly add the melted 2-chloro-6-nitrotoluene, plus the end of the reflux reaction for 3h. Cooling, add liquid alkali to adjust the pH to 8, steam distillation, to get 3-chloro-o-toluidine.
| Chemical Formula | C₇H₈ClN |
| Molecular Weight | 141.6 g/mol |
| Appearance | Brownish-red to colorless transparent oily liquid |
| Density | 1.171 g/mL at 25 °C or 1.185 g/cm³ |
| Melting Point | 2°C |
| Boiling Point | 245°C at 760 mmHg or 115-117°C at 1.33 kPa |
| Flash Point | 112.8°C or 110°C |
| Refractive Index | 1.588-1.59 |
| Solubility | Soluble in ethanol |
| Applications | Intermediate in the production of dyes (e.g., DB-50) and pesticides (e.g., quick-killing weeds in paddy fields) |
| Safety Information | Corrosive; wear protective gloves, goggles, and clothing; avoid inhaling vapors, aerosols, or gases; classified as flammable liquid (Category 4), skin corrosive (Category 1B), and causing serious eye damage (Category 1) under GHS |
| Regulatory Status | CAS No.: 87-60-5; EINECS No.: 201-756-6; Hazardous goods transport code: UN 3429 6.1/PG 3; Hazard symbols: Corrosive, harmful to the environment; Safety phrases: S26, S45, S61, S36/S37/S39; Risk phrases: R22, R34, R43, R51/53 |
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