Pharmaceutical Materials

Production method Obtained from o-nitrotoluene by chlorination and reduction.1.ChlorinationIn o-nitrotoluene, add 2% of ferric trichloride as a catalyst, pass chlorine at 50-60 ℃, until the relative density of the reaction liquid reaches 1.27-1.29 (50 ℃), wash with 5% hydrochloric acid, then wash with water, and finally adjust the pH with liquid alkali as 7. Separate out the aqueous layer, after evaporating the water, and then carry out decompression distillation to collect the fraction of 120-150 ℃ (5.33-8.0kPa). 120-150 ℃ (5.33-8.0kPa) fraction, cooling crystallization, filtration, to get 2-chloro-6-nitrotoluene.2. Reduction of hydrochloric acid and iron powder added to the reaction pot stirring and heating to 90 ℃, slowly add the melted 2-chloro-6-nitrotoluene, plus the end of the reflux reaction for 3h. Cooling, add liquid alkali to adjust the pH to 8, steam distillation, to get 3-chloro-o-toluidine.

3-Chloro-2-methylaniline Technical Summary

Property	Specification
Chemical Name	3-Chloro-2-methylaniline
Synonyms	3-Chloro-o-toluidine; 2-Amino-6-chlorotoluene
CAS Number	[CAS number would be inserted here if available]
Molecular Formula	C₇H₈ClN
Molecular Weight	141.60 g/mol
Appearance	Light yellow to brown liquid or crystalline solid
Melting Point	2-5°C
Boiling Point	235-237°C
Density	1.17 g/cm³ at 20°C
Solubility	Soluble in organic solvents, slightly soluble in water

Chemical Characteristics

Parameter	Value/Description
Purity	≥98% (typical)
Refractive Index	1.583-1.585 at 20°C
Flash Point	>110°C
Vapor Pressure	0.03 mmHg at 20°C
Stability	Stable under normal conditions

Key Applications

Industry	Function
Dye Manufacturing	Intermediate for azo dyes
Pharmaceuticals	Building block for drug synthesis
Agrochemicals	Pesticide intermediate
Chemical Research	Specialty organic synthesis

Safety & Handling

Aspect	Information
Toxicity	Harmful if swallowed/inhaled
Skin Contact	Causes irritation
Eye Contact	Causes severe irritation
Environmental Hazard	Toxic to aquatic life
Storage Conditions	Keep tightly closed in cool, ventilated area
Protective Measures	Use gloves, goggles and respirator

Note: This chlorinated aromatic amine requires careful handling due to its potential toxicity. The methyl and chloro substituents on the aniline ring make it a versatile intermediate for various chemical syntheses.

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