Pharmaceutical Materials

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is a key intermediate in pharmaceutical synthesis, particularly in the production of tyrosine kinase inhibitors (TKIs) such as nilotinib. Its structure features a trifluoromethyl-substituted benzene ring fused with a 4-methylimidazole moiety and an amino group, conferring unique reactivity and bioactivity. This compound enables selective functionalization via nucleophilic substitution and metal-catalyzed coupling reactions, facilitating the construction of complex drug scaffolds. Industrial synthesis routes typically involve imidazole ring formation and trifluoromethyl substitution. Its high purity (≥98%) and stability make it indispensable in TKI manufacturing, where trifluoromethyl groups enhance metabolic stability and binding affinity to target proteins. Due to its air-sensitivity and potential toxicity, it requires storage under inert conditions.

Usage： Used as pharmaceutical intermediate and other organic synthetic intermediates.

Packaging and Shipping：25KG/drum.

Storage: Keep container sealed and store in an ventilated, low temperature, dry warehouse, separate from foods and oxidizing agents.

 

Name	3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
Synonyms	NILOTINIB IMPURITY 24 Nilotinib EP Impurity A 3-(4-Methyl-1-imidazolyl)-5-(trifluoromethyl)aniline 1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole 3-(4-Methyl-iMidazol-1-yl)-5-trifluoro-MethylphenylaMine 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 3-(trifluoromethyl)-5-(4-methyl-1H-imidazol-1-yl)benzenamine 4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl) benzene amine
CAS	641571-11-1
EINECS	688-269-6
InChI	InChI=1/C11H10F3N3/c1-7-5-17(6-16-7)10-3-8(11(12,13)14)2-9(15)4-10/h2-6H,15H2,1H3
InChIKey	WWTGXYAJVXKEKL-UHFFFAOYSA-N

Molecular Formula	C11H10F3N3
Molar Mass	241.21
Density	1.35
Melting Point	124-126°C
Boling Point	372.14℃[at 101 325 Pa]
Flash Point	183.5°C
Water Solubility	228.6mg/L at 25℃
Vapor Presure	0Pa at 25℃
Appearance	powder to crystal
Color	White to Light gray to Light yellow
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.553
Use	Nilotinib Intermediate

,Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.

If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.