3-(2-Chloroacetyl)pyridine hydrochloride
Biomedicine 2025-03-04
CAS.No：61889-48-3
Appearance:White powder
Molecular Formula:C7H7Cl2NO
Purity:HPLC≥99.5%
Molecular weight:0
Capacity:20 tons/month
Application:Pharmaceutical intermediates
Basic Information of 3-(2-Chloroacetyl)pyridine Hydrochloride
| Aspect | Details |
|---|---|
| Chemical Name | 3-(2-Chloroacetyl)pyridine Hydrochloride |
| CAS Number | 61889-48-3 |
| Molecular Formula | C₇H₇Cl₂NO |
| Molecular Weight | 192.04 g/mol |
| Appearance | White to yellow crystal powder |
| Melting Point | 245-250°C (decomp) |
| Solubility | Soluble in water and some organic solvents |
| Storage Conditions | Under inert gas (nitrogen or argon) at 2-8°C |
Additional Information on 3-(2-Chloroacetyl)pyridine Hydrochloride
| Aspect | Details |
|---|---|
| Synonyms | 2-Chloro-1-(3-pyridinyl)ethanone hydrochloride, Chloroacetylpyridine Hydrochloride, 2-Chloro-1-(pyridin-3-yl)ethan-1-one hydrochloride |
| Applications | – Pharmaceutical Synthesis: Used as a synthetic intermediate for the preparation of chiral amino(pyridinyl)ethanol.<br>- Enzymatic Kinetic Resolution: Utilized in the lipase-mediated kinetic resolution process to produce chiral compounds.<br>- Anticancer Drug Synthesis: Used in the synthesis of the anticancer drug cyclophosphamide. |
| Preparation Method | – Synthesized by reacting 2-chloroacetic acid with pyridine in an anhydrous environment, followed by reaction with hydrochloric acid to form the hydrochloride salt. |
| Safety Information | – Hazard Statements: H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation).<br>- Precautionary Statements: P264 (Wash hands thoroughly after handling), P270 (Do not eat, drink, or smoke when using), P280 (Wear protective gloves/protective clothing/eye protection/face protection), P301+P312 (IF SWALLOWED: Call a POISON CENTER/doctor/… if you feel unwell), P302+P352 (IF ON SKIN: Wash with plenty of water), P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing).<br>- Storage: Store in a cool, dry place under inert gas. |
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
