2,6-Dichloronicotinic acid
Biomedicine 2025-03-04
CAS.No：38496-18-3
Appearance:White powder
Molecular Formula:C6H3Cl2NO2
Purity:≥99.5%
Molecular weight:192
Capacity:20 tons/month
Application:Pharmaceutical intermediates
Basic Information of 2,6-Dichloronicotinic Acid
| Aspect | Details |
|---|---|
| Chemical Name | 2,6-Dichloronicotinic Acid (2,6-Dichloropyridine-3-carboxylic Acid) |
| CAS Number | 38496-18-3 |
| Molecular Formula | C₆H₃Cl₂NO₂ |
| Molecular Weight | 192.00 g/mol |
| Appearance | Off-white to yellow crystalline powder |
| Melting Point | 140-143°C (lit.) |
| Boiling Point | 351.2±37.0 °C (Predicted) |
| Density | 1.612±0.06 g/cm³ (Predicted) |
| Solubility | Soluble in DMSO, methanol |
| pKa | 1.77±0.28 (Predicted) |
| Storage Conditions | Keep in a dark place, sealed in a dry environment, at room temperature |
Additional Information on 2,6-Dichloronicotinic Acid
| Aspect | Details |
|---|---|
| Synonyms | 2,6-Dichloro-3-pyridinecarboxylic acid, 3-Pyridinecarboxylic acid, 2,6-dichloro- |
| Applications | – Pharmaceuticals: Used as an intermediate in the synthesis of pyridine derivatives that inhibit human 11β-hydroxysteroid dehydrogenase type 1 enzyme.<br>- Fine Chemicals: Used in the production of agrochemicals, dyes, and other specialty chemicals. |
| Synthesis | Typically synthesized by chlorination of nicotinic acid derivatives, such as the reaction of 2,6-dichloropyridine with carbon dioxide under high pressure and temperature. |
| Safety Information | – Hazard Statements: Causes skin irritation (H315), causes serious eye irritation (H319).<br>- Precautionary Statements: Wear protective gloves/protective clothing/eye protection/face protection (P280), use only outdoors or in a well-ventilated area (P271).<br>- Storage: Store in a cool, dry place. Keep container tightly closed in a dry place. |
| Market and Supply | – Available from suppliers like NINGBO INNO PHARMCHEM CO.,LTD., Sigma-Aldrich, TCI Chemical, and Alfa Aesar.<br>- Prices range from $10-30 per gram for small quantities. |
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