Pharmaceutical Materials

CAS No.19646-07-2

 

Attribute	Details
Chemical Name	2.4-Dichloro-5-methoxypyrimidine
CAS Number	19646-07-2
Synonyms	5-Methoxy-2.4-dichloropyrimidine; 2.4-Dichloro-5-methoxy-1.3-diazine; Pyrimidine, 2.4-dichloro-5-methoxy-
Molecular Formula	C5H4Cl2N2O
Molecular Weight	179.00 g/mol
Appearance	White or pale yellow solid
Melting Point	68°C
Boiling Point	259.9°C at 760 mmHg
Flash Point	111°C
Density	1.446 g/cm³
Refractive Index	1.541
Solubility	Good solubility in polar solvents, poor solubility in water
Usage	Used as an intermediate in organic synthesis, particularly in the synthesis of heterocyclic compounds. It is also a key intermediate in the pharmaceutical industry for the production of certain drugs.
Reactivity	The chlorine atoms at the 2- and 4-positions can undergo substitution reactions, with the 4-position chlorine atom being more reactive.
Synthesis Method	Typically synthesized by reacting 5-methoxyuracil with pyridine and phosphorus oxychloride under high temperature and pressure.
Safety Information	Handle with care. May be irritating to skin and eyes. Store in a cool, dry place, away from heat and flame. Refer to the Material Safety Data Sheet (MSDS) for detailed safety precautions and disposal methods.

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