2,3,5-Collidine

Pharmaceutical Materials 2025-03-02

CAS Number: 695-98-7

Molecular Formula: C8H11N

Molecular Weight: 121.18 g/mol

Appearance: Colorless or pale yellow liquid

Boiling Point: 185°C

Usage: Used as a pharmaceutical intermediate and a good solvent.

 

Aspect Details
Name 2.3.5-Collidine
Common Synonyms 2.3.5-Trimethylpyridine; 2.3.5-Lutidine
CAS No. 108-75-8
Molecular Formula C₈H₁₁N
Molecular Weight 121.18 g/mol
Physical Properties
  • Appearance: Colorless to pale yellow liquid
  • Boiling Point: 189-191 °C
  • Melting Point: -13 °C
  • Solubility: Soluble in organic solvents (e.g., ethanol, ether); slightly soluble in water
  • Density: 0.93 g/cm³
Chemical Properties A tertiary amine with a pyridine ring substituted with three methyl groups at positions 2. 3. and 5. It is a stronger base than pyridine due to the electron-donating effects of the methyl groups, enhancing its nucleophilicity and reactivity in substitution reactions.
Applications
  • Used as a solvent and catalyst in organic synthesis
  • Employed in pharmaceuticals for the preparation of nucleoside analogs
  • Acts as a ligand in coordination chemistry and as a base in acid-base titrations
Safety Information
  • Handle with caution due to its irritant properties; avoid inhalation and prolonged skin contact
  • Store in a cool, dry place away from strong acids and oxidizing agents

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