2,3,4,6-Tetra-O-trimethylsilyl-D-gluconolactone Cas：32384-65-9
Pharmaceutical Materials 2025-03-02
2,3,4,6-Tetra-O-trimethylsilyl-D-gluconolactone, with a CAS number of 32384-65-9, is an important organic compound with a wide range of applications. This compound is characterized by its tetra-O-trimethylsilyl substitution on the glucose ring, which imparts unique chemical and physical properties. It is a valuable intermediate in the synthesis of various pharmaceutical drugs, particularly in the development of anti-diabetic medications such as dapagliflozin and canagliflozin. Due to its stability and reactivity, 2,3,4,6-Tetra-O-trimethylsilyl-D-gluconolactone is often used in the preparation of glucose derivatives and other complex carbohydrates. Its molecular structure, with four trimethylsilyl groups attached to the glucose ring, allows for precise control over the reactivity and selectivity in organic synthesis.
| Compound Information | Details |
|---|---|
| Name | 2,3,4,6-Tetra-O-trimethylsilyl-D-gluconolactone |
| CAS Number | 32384-65-9 |
| Molecular Formula | C18H42O6Si4 |
| Molecular Weight | 466.86448 g/mol |
| Appearance | Colorless to pale yellow oily liquid |
| Density | 0.97 g/mL |
| Boiling Point | 417 °C |
| Flash Point | 171 °C |
| Purity | Typically 97%-99% |
| Applications | Intermediate in the synthesis of pharmaceutical drugs, particularly anti-diabetic medications. Used in the preparation of glucose derivatives and other complex carbohydrates. |
| Storage Conditions | Store in a cool, dry place away from light and moisture. |
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