2,3,4,5-Tetrafluorobenzoyl chloride
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Category：Pharmaceutical Materials Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
CAS Number: 94695-48-4
Molecular Formula: C7HClF4O
Molecular Weight: 212.53
Appearance: Colorless to pale yellow liquid
Usage: Mainly used as an intermediate in the synthesis of various pharmaceutical and pesticide compounds.
Hazard: Corrosive, requires proper safety measures during handling.
| Aspect | Details |
|---|---|
| Name | 2.3.4.5-Tetrafluorobenzoyl Chloride |
| Synonyms | Tetrafluorobenzoyl chloride; Perfluorobenzoyl chloride (partial misnomer, as it lacks 6-fluorine) |
| CAS Number | 1508-21-5 |
| Chemical Formula | C₇HClF₄O |
| Molecular Weight | 212.52 g/mol |
| Physical Properties | – Appearance: Colorless to pale yellow liquid |
| – Boiling Point: 142–144°C (at 760 mmHg) | |
| – Solubility: Reacts with water; soluble in organic solvents (e.g., dichloromethane, toluene) | |
| Synthetic Route | Prepared via chlorination of 2.3.4.5-tetrafluorobenzoic acid using reagents like thionyl chloride (SOCl₂) |
| Applications | – Pharmaceuticals: Intermediate in synthesizing fluoroquinolone antibiotics (e.g., via acylation reactions) |
| – Agrochemicals: Building block for pesticides and herbicides | |
| – Materials Science: Used in fluoropolymer synthesis | |
| Safety Precautions | – Handling: Wear PPE; avoid moisture due to hydrolytic reactivity |
| – Storage: Keep in airtight containers under inert gas (e.g., nitrogen) at low temperatures |
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