2,3-Difluorophenylboronic acid
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Category：Semiconductor Display Materials MOQ:100KG Shipped directly from China
Introduction
2.3-Difluorophenylboronic acid is an organoboron compound with two fluorine substituents on the phenyl ring and a boronic acid group. This compound is widely used in organic synthesis and material science due to its unique reactivity and structural properties.
Key Properties
| Property | Details |
|---|---|
| IUPAC Name | 2.3-Difluorophenylboronic acid |
| CAS Number | 121219-16-7 |
| Molecular Formula | C₆H₅BF₂O₂ |
| Molecular Weight | 157.91 g/mol |
| Category | Pharmaceutical intermediate |
| Appearance | Off-white to light beige crystalline powder |
| Boiling Point | ~274.8°C |
| Melting Point | 95°C |
| Density | ~1.35 g/cm³ |
| Refractive Index | 1.485 |
| Flash Point | 120°C |
| Storage Conditions | 0-6°C |
| Synthesis Method | Grignard reagent reaction with trimethyl borate |
| Applications | Organic synthesis, medicinal chemistry, development of novel pharmaceuticals |
Synthesis
2.3-Difluorophenylboronic acid can be synthesized via a Grignard reagent reaction. The process involves reacting 3-fluorobromobenzene with magnesium turnings in 2-methyltetrahydrofuran under nitrogen atmosphere to generate the Grignard reagent, which is then reacted with trimethyl borate. After hydrolysis and recrystallization, 2.3-Difluorophenylboronic acid is obtained.
Applications
In organic synthesis, 2.3-Difluorophenylboronic acid serves as a valuable building block for the preparation of complex molecules, particularly those requiring defined stereochemistry and functionality. The difluorophenylboronic acid moiety makes it a promising candidate for the development of novel pharmaceuticals, agrochemicals, and functional materials. The boronic acid group can be further transformed into other functional groups, expanding the scope of its applications.
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