2,3-dichloro-5-(trifluoromethyl)pyridine CAS: 69045-84-7
Category：Chemical Intermediates
Introduction
Product use: Intermediate of insecticides imidacloprid and fluazuron, and can also be used to synthesize herbicide fluazuron (Gaicao Neng).
Fluazuron and chlorfluazuron intermediate, used for synthesis of haloxyfo-F-methyl.
The use and synthesis method of dichlorotrifluoromethylpyridine.
The preparation method is to use 2-amino-5-methylpyridine as raw material, first undergo chlorination, then diazotization, react in the presence of CuCl to obtain 2,3-dichloro-5-trichloromethylpyridine, and then react with hydrogen fluoride to obtain the product.
It is also possible to use 2-chloro-5-methylpyridine as the raw material, first perform side chain chlorination to obtain 2-chloro-5-trichloromethylpyridine, then further ring chlorination to obtain 2,3-dichloro-5-trichloromethylpyridine, and then fluorinate with hydrogen fluoride to obtain the product.
The preparation method involves using 3-methylpyridine as the raw material in the presence of a catalyst, followed by chlorination and fluorination to produce this product.
Alternatively, 2-chloro-5-trichloromethylpyridine can be chlorinated on the ring to obtain 2,3-dichloro-5-trichloromethylpyridine, which can then be fluorinated with hydrogen fluoride to obtain the product.
| Name | 2,3-dichloro-5-(trifluoromethyl)pyridine |
| Synonyms | DCTF 5-DCTF 2, 3 – dichloro – 5-3 Methyl pyridine 2,3-DICHLORO-5-(TRIFLUOROMETHYL)PYRIDINE 2,3-dichloro-5-(trifluoromethyl)pyridine 2,3- two-5- three fluorineMethyl pyridinechloride 5,6-Dichloro-alpha,alpha,alpha-trifluoro-3-picoline |
| CAS | 69045-84-7 |
| EINECS | 410-340-5 |
| InChI | InChI=1/C12H10ClF3N2O/c1-6(2)18-9-4-3-7(10(13)19)5-8(9)17-11(18)12(14,15)16/h3-6H,1-2H3 |
| Molecular Formula | C6H2Cl2F3N |
| Molar Mass | 215.99 |
| Density | 1.549g/mLat 25°C(lit.) |
| Melting Point | 8-9 °C |
| Boling Point | 80°C20mm Hg(lit.) |
| Flash Point | 175°F |
| Vapor Presure | 0.00017mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.549 |
| Color | Clear colorless to yellow |
| pKa | -3.34±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | n20/D 1.475(lit.) |
| Physical and Chemical Properties |
Melting Point: 8 – 9 Boiling Point: 176 |
| Risk Codes | R20/22 – Harmful by inhalation and if swallowed. R41 – Risk of serious damage to eyes R43 – May cause sensitization by skin contact R51/53 – Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S24 – Avoid contact with skin. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 – Wear suitable gloves and eye/face protection S61 – Avoid release to the environment. Refer to special instructions / safety data sheets. S36 – Wear suitable protective clothing. |
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