2,3-Dichloro-5-(trifluoromethyl)pyridine
Agrochemicals 2025-03-02
2,3-Dichloro-5-(trifluoromethyl)pyridine (CAS No. 69045-83-6)
1. Basic Information
- IUPAC Name: 2,3-Dichloro-5-(trifluoromethyl)pyridine
- Synonyms:
- DCTF
- 5-Trifluoromethyl-2,3-dichloropyridine
- CAS Number: 69045-83-6
- Molecular Formula: C₆H₂Cl₂F₃N
- Molecular Weight: 215.99 g/mol
- Appearance: White to off-white crystalline solid
- Odor: Slight halogenated odor
2. Physical and Chemical Properties
| Property | Value |
|---|---|
| Melting Point | 48–52°C (118–126°F) |
| Boiling Point | 185–188°C (365–370°F) |
| Density | 1.62 g/cm³ (20°C) |
| Solubility | – Water: Insoluble |
| – Organic solvents: Soluble in ethanol, acetone, DCM | |
| Vapor Pressure | 0.15 mmHg at 25°C |
| Log Pow | 2.8 (octanol/water) |
3. Chemical Structure
Cl
|
N=◯-CF₃
|
Cl
(◯ = pyridine ring with substitutions at positions 2, 3, and 5)
4. Hazards (GHS Classification)
- Health Hazards:
- Harmful if swallowed (H302)
- Causes skin irritation (H315)
- Causes serious eye irritation (H319)
- Environmental:
- Very toxic to aquatic life (H400)
- Persistent and bioaccumulative (H413)
- NFPA Rating: Health 2, Flammability 1, Reactivity 1
5. Storage and Handling
- Storage:
- Keep in tightly sealed amber containers
- Store in a cool, dry, well-ventilated area
- Handling:
- Use nitrile gloves, safety goggles, and a fume hood
- Avoid dust generation
6. Applications
- Agrochemicals:
- Key intermediate for herbicides (e.g., fluazifop-butyl)
- Pharmaceuticals:
- Building block for antiviral drugs
- Organic Synthesis:
- Precursor for cross-coupling reactions (e.g., Suzuki, Stille)
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