2,2′,4′-Trichloroacetophenone

Pharmaceutical Materials 2025-03-02

CAS Number: 4252-78-2

Molecular Formula: C8H5Cl3O

Molecular Weight: 223.48

Appearance: Brown or off-white crystalline solid

Melting Point: 47-54°C

Boiling Point: 130-135°C at 4 mmHg

Density: 1.312 g/cm3

Usage: Used as an intermediate in pesticides and pharmaceuticals.

 

Aspect Details
Name 2.2′,4′-Trichloroacetophenone
CAS No. 4252-78-2
Molecular Formula C8H5Cl3O
Molecular Weight 223.48 g/mol
Physical Properties
  • Appearance: Brown crystals
  • Density: 1.312 g/cm³
  • Melting Point: 47-54 °C
  • Boiling Point: 130-135 °C (4 mmHg)
  • Flash Point: 122.1 ± 23.7 °C
  • Solubility: 60 mg/L (20 °C in water)
Chemical Properties 2.2′,4′-Trichloroacetophenone is stable under normal conditions but should be stored away from strong oxidizing agents. It is sensitive to moisture and light, requiring sealed, dry, and cool storage conditions.
Applications Used as an intermediate in the production of pesticides and pharmaceuticals, particularly in the synthesis of antifungal agents such as miconazole nitrate and econazole nitrate.
Safety Information Classified as hazardous (Xi, C, N, T), it requires protective equipment during handling and appropriate disposal methods to prevent environmental contamination.

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