2,2,2-Trifluoroethanol

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Category:Chemical Additives   Own Brand:MT  /MOQ:100KG  /From China/  B2B only.

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Introduction

2,2,2-Trifluoroethanol (TFE)

Chemical Formula: C₂H₃F₃O
Structure: Fluorinated alcohol with ​three fluorine atoms (-F) replacing all hydrogens on the carbon adjacent to the ​hydroxyl group (-OH) in ethanol. Combines properties of alcohols and fluorinated compounds.


Physical Properties

  • Appearance: Clear, colorless liquid.
  • Odor: Mild alcohol-like.
  • Solubility: Highly polar; ​miscible with water and most organic solvents.

Applications

  1. Biochemical & Polymer Chemistry:
    • Solvent for stabilizing ​secondary structures of peptides, proteins, and ​polymers.
  2. Organic Synthesis:
    • Reagent for synthesizing ​fluorinated compounds; production of ​pharmaceuticals and ​agrochemicals.
  3. Analytical Chemistry:
    • Solvent in ​NMR spectroscopy (deuterium-free properties).

Safety Considerations ⚠️

  • Health Hazards:
    • Toxic; causes ​severe irritation to skin, eyes, and respiratory system.
  • Handling:
    • Use ​PPE (gloves, goggles, lab coat) and work in a ​well-ventilated area/fume hood.
  • Storage:
    • Store in a ​cool, dry place away from ​heat and incompatible substances.

Summary:
2,2,2-Trifluoroethanol’s ​fluorination-enhanced polarity and ​biocompatibility make it indispensable in biochemical research and fluorinated compound synthesis. Its utility in NMR and industrial applications is tempered by ​strict safety protocols due to toxicity risks.

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