2,2,2-trifluoro-1-(3,4,5-trichlorophenyl)ethanone CAS No.: 158401-00-4
Pharmaceutical Materials 2025-03-03
2,2,2-Trifluoro-1-(3,4,5-trichlorophenyl)ethanone (CAS No. 158401-00-4) is a specialized trifluoromethylated ketone with significant applications in pharmaceutical intermediates, particularly in the synthesis of antiparasitic agents like Lotilaner. Its molecular formula, C₈H₂Cl₃F₃O, and molecular weight of 277.46 g/mol highlight its unique trifluoromethyl and trichlorophenyl functional groups, which confer enhanced metabolic stability and lipophilicity. This compound is critical in developing drugs targeting pests and parasites, leveraging its structural stability and reactivity. Despite its utility, it poses hazards such as skin and eye irritation, requiring careful handling under GHS-compliant conditions. Its role in advanced intermediates underscores its importance in modern medicinal chemistry, balancing efficacy with safety considerations.
Usage： It is used as pharmaceutical intermedaite and vermifuge Lotilaner intermediate.
Packaging and Shipping： 40KG/drum or 300KG/drum.
Storage: Keep container sealed and store in an ventilated, low temperature, dry warehouse, separate from foods and oxidizing agents.
| Name | 2,2,2-Trifluoro-1-(3,4,5-trichlorophenyl)ethanone |
| Synonyms | 2,2,2-Trifluoro-3′,4′,5′-trichloroacetophenone 3′,4′,5′-Trichloro-2,2,2,-trifluoroacetophenone 2,2,2-Trifluoro-1-(3,4,5-trichlorophenyl)ethanone 2,2,2-trifluoro-1-(3,4,5-trichlorophenyl)ethanone Ethanone, 2,2,2-trifluoro-1-(3,4,5-trichlorophenyl)- |
| CAS | 158401-00-4 |
| InChI | InChI=1S/C8H2Cl3F3O/c9-4-1-3(2-5(10)6(4)11)7(15)8(12,13)14/h1-2H |
| Molecular Formula | C8H2Cl3F3O |
| Molar Mass | 277.46 |
| Density | 1.601±0.06 g/cm3(Predicted) |
| Boling Point | 316.7±42.0 °C(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
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