2-Thiouracil
Pharmaceutical Materials 2025-03-03
CAS Number: 141-90-2
Molecular Formula: C4H4N2OS
Molecular Weight: 128.15 g/mol
Appearance: White to off-white crystalline powder
Melting Point: Above 300°C
Boiling Point: 337.2°C
Usage: Used as an intermediate in the synthesis of anticancer, anti-cardiovascular, and antidiabetic drugs.
| Category | Details |
|---|---|
| Basic Information | |
| Name | 2-Thiouracil |
| CAS Number | 141-90-2 |
| Molecular Formula | C4H4N2OS |
| Molecular Weight | 128.152 g/mol |
| EINECS Number | 205-508-8 |
| MDL Number | MFCD00006039 |
| Appearance | White to off-white crystalline powder or light yellow powder |
| Density | 1.5±0.1 g/cm³ |
| Boiling Point | 337.2ºC at 760 mmHg |
| Melting Point | >300°C |
| Solubility | 0.5 g/L in water, soluble in alkaline solutions |
| Soluble in DMSO and other organic solvents | |
| Chemical Properties | |
| pH (5% solution in 2N NaOH) | Light yellow, clear |
| Loss on Drying | ≤0.5% (at 105°C for 3 hours) |
| Sulfated Ash | ≤0.1% |
| Heavy Metals (as Pb) | ≤20 ppm |
| Applications | |
| Medical Use | As an anti-thyroid compound |
| Research | As a research reagent for early detection, targeting metastatic melanoma |
| Biological Activity | Selective inhibitor of neuronal nitric oxide synthase |
| Safety Information | Warning (GHS08); Xn, T danger categories; R40-R45-R20/21/22 risk codes |
| Storage Conditions | Store in a well-closed container in a cool, dry place |
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