2-Thiophenecarbonyl chloride
Pharmaceutical Materials 2025-03-02
CAS Number: 5271-67-0
Molecular Formula: C5H3ClOS
Molecular Weight: 146.59 g/mol
Appearance: Clear colorless to yellow-gray liquid or transparent to slightly yellowish crystals
Boiling Point: 206-208 °C
Density: 1.371 g/mL at 25 °C
Usage: Used as an intermediate in pharmaceutical synthesis.
| Aspect | Details |
|---|---|
| Name | 2-Thiophenecarbonyl Chloride |
| CAS Number | 5493-05-8 |
| Chemical Formula | C₅H₃ClOS |
| Molecular Weight | 146.59 g/mol |
| Physical Appearance | Colorless to pale yellow liquid with a pungent odor |
| Boiling Point | 75-77°C (20 mmHg) |
| Melting Point | Not typically defined (liquid at room temperature under standard conditions) |
| Flash Point | 31°C (closed cup) |
| Density | 1.36 g/cm³ |
| Reactivity | Highly reactive; hydrolyzes rapidly in water to form thiophene-2-carboxylic acid and HCl. |
| Solubility | Soluble in organic solvents (e.g., ether, chloroform); reacts with alcohols and amines. |
| Applications | – Key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. |
| – Used in the production of thiophene-based dyes and polymers. | |
| Safety Information | – Toxic and corrosive; causes severe eye, skin, and respiratory irritation. |
| – Flammable; handle under inert atmosphere with appropriate PPE. | |
| Storage Conditions | Store in a cool, dry, and well-ventilated area, away from moisture and heat. |
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