2-Thiopheneacetyl chloride
Pharmaceutical Materials 2025-03-02
CAS Number: 39098-97-0
Molecular Formula: C6H5ClOS
Molecular Weight: 160.62 g/mol
Appearance: Clear brown liquid
Usage: It is widely used in the pharmaceutical, chemical, and food industries as an intermediate in the production of various compounds.
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| Attribute | Details |
|---|---|
| Chemical Name | 2-Thiopheneacetyl Chloride |
| Synonyms | 2-Thiopheneacetyl chloride; Thiophene-2-acetyl chloride; 2-Acetylchlorothiophene; 2-(2-Thienyl)acetyl chloride; 2-Thienylacetyl chloride; 2-Thiopheneacetyl chloride (TAC) |
| CAS Number | 39098-97-0 |
| Molecular Formula | C6H5ClOS |
| Molecular Weight | 160.62 g/mol |
| Appearance | Clear brown liquid or colorless to pale yellow liquid |
| Density | 1.303 g/mL at 25 °C |
| Boiling Point | 105-106 °C at 22 mmHg; 130-135 °C at 90 mmHg |
| Vapor Pressure | 4 mm Hg at 83 °C |
| Refractive Index | 1.551 (lit.) |
| Flash Point | 215 °F (101.7 °C) |
| Sensitivity | Moisture Sensitive |
| Stability | Stable under normal conditions; reacts with water |
| Uses | Used as a reagent in organic synthesis; specifically in the synthesis of diamide derivatives of (S)-BINOL, Nitrocefin, and other compounds; also used as a medical intermediate |
| Production Method | Prepared by reacting 2-thiopheneacetic acid with thionyl chloride in a glass-lined reactor, heated with a water bath at 40-50 °C for 4 hours, followed by distillation to remove excess thionyl chloride and low-boiling impurities |
| Safety Instructions | Handle with caution; avoid contact with skin, eyes, and inhalation of vapors; store in a cool, dry place away from moisture and heat; refer to the MSDS for detailed safety information |
