2-Tetrahydrofuroic acid
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Category：Pharmaceutical Materials Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
CAS Number: 16874-33-2
Molecular Formula: C5H8O3
Molecular Weight: 116.115 g/mol
Appearance: Colorless to light yellow liquid
Melting Point: 21°C
Boiling Point: 243.2°C at 760 mmHg
Usage: Used as an intermediate in pharmaceutical synthesis.
| Attribute | Details |
|---|---|
| Chemical Name | 2-Tetrahydrofuroic Acid |
| Synonyms | Tetrahydrofuran-2-carboxylic Acid; 2-Furoic acid, tetrahydro-; 2-Tetrahydrofuranoic Acid; (±)-Tetrahydrofuran-2-carboxylic Acid; Tetrahydro-2-furancarboxylic acid; R-Tetrahydrofuran-2-carboxylic acid; S-Tetrahydrofuran-2-carboxylic acid |
| CAS Number | 16874-33-2 |
| Molecular Formula | C5H8O3 |
| Molecular Weight | 116.12 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Density | Approximately 1.262 g/cm³ (may vary slightly depending on temperature and purity) |
| Boiling Point | 243.19 °C (or 243.2±0.0 °C at 760 mmHg, or 244 °C at 736 mmHg) |
| Melting Point | 21 °C |
| Flash Point | 113.21 °C (or 113.2±18.9 °C, or 139 °C) |
| Solubility | Soluble in chloroform, dimethyl sulfoxide (DMSO), methanol, and other organic solvents; also soluble in water |
| Chemical Properties | 2-Tetrahydrofuroic acid is a stable compound under normal conditions. It has one carboxylic acid group, which can participate in typical reactions of carboxylic acids, such as esterification and acid-base reactions. |
| Applications | It serves as an intermediate in pharmaceutical synthesis. It can be chirally resolved to obtain (R)-2-THFA and (S)-2-THFA, which are important ligands in asymmetric synthesis reactions. (R)-2-THFA is a key intermediate in the synthesis of antibiotics such as furopenam, while (S)-2-THFA is used in the preparation of cephalosporin antibiotics and other intermediates. |
| Safety Information | Handle with caution. Avoid contact with skin, eyes, and clothing. Wear appropriate protective clothing, gloves, and eye protection. Store in a cool, dry place away from incompatible materials and oxidizing agents. Follow local regulations for the safe handling and disposal of chemicals. |
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