Pharmaceutical Materials

CAS Number: 527-73-1

Molecular Formula: C3H3N3O2

Molecular Weight: 113.07 g/mol

Appearance: Yellow to orange powder

Melting Point: 287 °C

Boiling Point: 373.6 °C

Density: 1.6±0.1 g/cm³

Usage: Used as an intermediate in organic synthesis.

 

Property	Details
Chemical Name	2-Nitroimidazole
Synonyms	Azomycin, 2-Nitro-1H-imidazole, 2-Nitro-imidazole
CAS Number	527-73-1
EINECS Number	208-425-5
Molecular Formula	C₃H₃N₃O₂
Molecular Weight	113.08 g/mol
Physical State	Yellow to orange crystalline powder
Melting Point	287 °C (decomposes)
Boiling Point	373.6 °C at 760 mmHg
Density	1.552–1.6 g/cm³
Solubility	Insoluble in water; soluble in organic solvents like DMSO, methanol, and ethanol.
Applications	– Radiosensitizers: Key intermediate in synthesizing tumor radiosensitizers (e.g., Misonidazole, Pimonidazole). – Antimicrobial Agents: Exhibits activity against aerobic and anaerobic bacteria. – Prodrug Development: Utilized in hypoxia-activated prodrugs for targeted cancer therapy. – Imaging Agents: Serves as a precursor for hypoxia-selective imaging agents.
Health & Safety	– Toxicity: Acute oral toxicity (LD₅₀ in mice: 80 mg/kg i.v.). – Hazards: Flammable; causes skin, eye, and respiratory irritation. – Storage: Store in a cool, dry, well-ventilated area away from acids and oxidizing agents.

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