2-Nitroimidazole
Pharmaceutical Materials 2025-03-02
CAS Number: 527-73-1
Molecular Formula: C3H3N3O2
Molecular Weight: 113.07 g/mol
Appearance: Yellow to orange powder
Melting Point: 287 °C
Boiling Point: 373.6 °C
Density: 1.6±0.1 g/cm³
Usage: Used as an intermediate in organic synthesis.
| Property | Details |
|---|---|
| Chemical Name | 2-Nitroimidazole |
| Synonyms | Azomycin, 2-Nitro-1H-imidazole, 2-Nitro-imidazole |
| CAS Number | 527-73-1 |
| EINECS Number | 208-425-5 |
| Molecular Formula | C₃H₃N₃O₂ |
| Molecular Weight | 113.08 g/mol |
| Physical State | Yellow to orange crystalline powder |
| Melting Point | 287 °C (decomposes) |
| Boiling Point | 373.6 °C at 760 mmHg |
| Density | 1.552–1.6 g/cm³ |
| Solubility | Insoluble in water; soluble in organic solvents like DMSO, methanol, and ethanol. |
| Applications | – Radiosensitizers: Key intermediate in synthesizing tumor radiosensitizers (e.g., Misonidazole, Pimonidazole). – Antimicrobial Agents: Exhibits activity against aerobic and anaerobic bacteria. – Prodrug Development: Utilized in hypoxia-activated prodrugs for targeted cancer therapy. – Imaging Agents: Serves as a precursor for hypoxia-selective imaging agents. |
| Health & Safety | – Toxicity: Acute oral toxicity (LD₅₀ in mice: 80 mg/kg i.v.). – Hazards: Flammable; causes skin, eye, and respiratory irritation. – Storage: Store in a cool, dry, well-ventilated area away from acids and oxidizing agents. |
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