2-Ketoglutaric acid CAS 328-50-7
Pharmaceutical Materials 2025-03-03
2-Ketoglutaric acid (2-KG), also known as α-ketoglutaric acid, is a crystalline organic compound with the molecular formula C₅H₆O₅. As a key intermediate in the tricarboxylic acid (TCA) cycle, it plays a vital role in cellular energy metabolism and amino acid homeostasis. Its ability to act as a carbon skeleton for nitrogen assimilation and a reversible inhibitor of tyrosinase (IC₅₀ = 15 mM) underscores its biochemical significance. Beyond metabolism, 2-KG serves as a dietary supplement to enhance athletic performance, improve mitochondrial function, and potentially delay aging by reducing oxidative stress. Industrial applications include its use in pharmaceuticals, biotechnology (e.g., microbial fermentation), and as a flavoring agent in food. Despite its low toxicity, prolonged exposure may cause eye irritation, necessitating proper handling precautions.
2-Ketoglutaric acid CAS 328-50-7 Usage： It can be used as a nutritional fortifier, as a component of sports nutrition drinks, organic intermediates, biochemical reagents, supporting reagents for measuring liver function, and physical strengthening supplements. In addition, α‑ 1:1 and 2:1 L ‑ arginine can be prepared from ketoglutarate α‑ Ketoglutarate, used as a sports nutrient.
Packaging and Shipping： 25kgs/Drum or as required by buyer.
Storage: Ventilated low temperature drying warehouse;Store separately with food raw materials, oxidants and halogenated hydrocarbons.
| Name | 2-Ketoglutaric acid |
| Synonyms | KETO-GLU FEMA 3891 Oxoglutaric acid -Ketoglutaricacid 2-oxopentanedioate α-Ketoglutaricacid 2-Oxoglutaric acid N-oxoglutamic acid A-KETOGLUTARIC ACID α-Ketoglutaric acid 2-KETOGLUTARIC ACID 2-Ketoglutaric acid 2-Ketoglutaric acid 2-OXOPENTANDIOICACID 2-Oxpentanedioicacid 2-oxo-pentanedioicaci Glutaric acid, 2-oxo- 2-Oxopentanedioic acid alpha-Ketoglutaric Acid GAMMA-KETOGLUTARIC ACID alpha-keto-Glutaric acid A-KetoglutaricAcidPuriss Glutaric acid, alpha keto KetoglutaricAcid,FreeAcid PENTANEDIOIC ACID, 2-OXO- 2-Oxo-1,5-pentanedioic acid 2-KETOGLUTARIC ACID BIOSYNTH diammonium 2-oxopentanedioate A-KETOGLUTARIC ACID FREE ACID 2-Oxo-1,5-dipentanedioic acid A-KETOGLUTARIC ACID FREE ACID CELL*CULTU RE TESTED 2-KETOGLUTARIC ACID, DISODIUM SALT, DIHYDRATE BIOTECh GRADE |
| CAS | 328-50-7 |
| EINECS | 206-330-3 |
| InChI | InChI:1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10) |
| Molecular Formula | C5H6O5 |
| Molar Mass | 146.1 |
| Density | 1.54g/cm3 |
| Melting Point | 113-115℃ |
| Boling Point | 320.7°C at 760 mmHg |
| Flash Point | 147.7°C |
| Solubility | Easily soluble in water, alcohol, acetone; extremely insoluble in ether |
| Vapor Presure | 6.5E-05mmHg at 25°C |
| Appearance | White fine crystalline powder. Long storage becomes light gray yellow |
| Storage Condition | 2-8℃ |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.544 |
| MDL | MFCD00004165 |
| Physical and Chemical Properties | Melting point 113-115°C |
| Use | Mainly as a component of sports nutrition drinks |
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