Pharmaceutical Materials

2-Ketoglutaric acid (2-KG), also known as α-ketoglutaric acid, is a crystalline organic compound with the molecular formula C₅H₆O₅. As a key intermediate in the tricarboxylic acid (TCA) cycle, it plays a vital role in cellular energy metabolism and amino acid homeostasis. Its ability to act as a carbon skeleton for nitrogen assimilation and a reversible inhibitor of tyrosinase (IC₅₀ = 15 mM) underscores its biochemical significance. Beyond metabolism, 2-KG serves as a dietary supplement to enhance athletic performance, improve mitochondrial function, and potentially delay aging by reducing oxidative stress. Industrial applications include its use in pharmaceuticals, biotechnology (e.g., microbial fermentation), and as a flavoring agent in food. Despite its low toxicity, prolonged exposure may cause eye irritation, necessitating proper handling precautions.

2-Ketoglutaric acid CAS 328-50-7 Usage： It can be used as a nutritional fortifier, as a component of sports nutrition drinks, organic intermediates, biochemical reagents, supporting reagents for measuring liver function, and physical strengthening supplements. In addition, α‑ 1:1 and 2:1 L ‑ arginine can be prepared from ketoglutarate α‑ Ketoglutarate, used as a sports nutrient.

Packaging and Shipping： 25kgs/Drum or as required by buyer.

Storage: Ventilated low temperature drying warehouse;Store separately with food raw materials, oxidants and halogenated hydrocarbons.

Name	2-Ketoglutaric acid
Synonyms	KETO-GLU FEMA 3891 Oxoglutaric acid -Ketoglutaricacid 2-oxopentanedioate α-Ketoglutaricacid 2-Oxoglutaric acid N-oxoglutamic acid A-KETOGLUTARIC ACID α-Ketoglutaric acid 2-KETOGLUTARIC ACID 2-Ketoglutaric acid 2-Ketoglutaric acid 2-OXOPENTANDIOICACID 2-Oxpentanedioicacid 2-oxo-pentanedioicaci Glutaric acid, 2-oxo- 2-Oxopentanedioic acid alpha-Ketoglutaric Acid GAMMA-KETOGLUTARIC ACID alpha-keto-Glutaric acid A-KetoglutaricAcidPuriss Glutaric acid, alpha keto KetoglutaricAcid,FreeAcid PENTANEDIOIC ACID, 2-OXO- 2-Oxo-1,5-pentanedioic acid 2-KETOGLUTARIC ACID BIOSYNTH diammonium 2-oxopentanedioate A-KETOGLUTARIC ACID FREE ACID 2-Oxo-1,5-dipentanedioic acid A-KETOGLUTARIC ACID FREE ACID CELL*CULTU RE TESTED 2-KETOGLUTARIC ACID, DISODIUM SALT, DIHYDRATE BIOTECh GRADE
CAS	328-50-7
EINECS	206-330-3
InChI	InChI:1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)

Molecular Formula	C5H6O5
Molar Mass	146.1
Density	1.54g/cm3
Melting Point	113-115℃
Boling Point	320.7°C at 760 mmHg
Flash Point	147.7°C
Solubility	Easily soluble in water, alcohol, acetone; extremely insoluble in ether
Vapor Presure	6.5E-05mmHg at 25°C
Appearance	White fine crystalline powder. Long storage becomes light gray yellow
Storage Condition	2-8℃
Sensitive	Easily absorbing moisture
Refractive Index	1.544
MDL	MFCD00004165
Physical and Chemical Properties	Melting point 113-115°C
Use	Mainly as a component of sports nutrition drinks

Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.

If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.