2-Iodoacetamide CAS No. 144-48-9
Category：Pharmaceutical Materials
Introduction
In proteomics, the alkylation reagent of histidine and cysteine, used for peptide sequencing and enzyme inhibitors. It is also used in organic synthesis.
Product Name
2-Iodoacetamide
Multiple Names
Iodoacetamide;
2-Iodacetamid;
2-Iodoacétamide
CAS No. 144-48-9
EC No. 205-630-1
MF No. C2H4INO
MW No. 184.96
Advantage of 2-Iodoacetamide CAS No. 144-48-9
The color is pure and free of impurities.
The transportation conditions are simple.
Easy storage and stable performance.
| Aspect | Details |
|---|---|
| Chemical Name | 2-Iodoacetamide |
| Aliases | Iodoacetamide; IAM |
| CAS Number | 143-19-1 |
| Molecular Formula | C₂H₄IN₂O |
| Molecular Weight | 198.97 g/mol |
| Physical State | White or off-white crystalline solid |
| Melting Point | 114 – 116°C |
| Solubility | Soluble in water, ethanol, and acetone. Its solubility in water makes it a useful reagent in aqueous-based reactions |
| Chemical Properties | A powerful alkylating agent due to the presence of the iodo group. The amide group provides some stability but also reactivity. It can react with nucleophiles such as thiols and amines, making it valuable in biochemical and chemical synthesis applications |
| Applications | – Biochemistry: Inhibits enzymes by alkylating cysteine residues, which is useful in studying enzyme mechanisms and structures. – Chemical Synthesis: Acts as a versatile intermediate in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals. It can be used to introduce iodine atoms into molecules for further transformations |
| Safety Precautions | Toxic and corrosive. Proper handling with gloves, goggles, and in a fume hood is essential to avoid skin, eye, and respiratory exposure |
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