2-Hydroxypyridine
Pharmaceutical Materials 2025-03-02
CAS Number: 142-08-5
Molecular Formula: C5H5NO
Molecular Weight: 95.10 g/mol
Appearance: White needle-like crystals or white to light yellow powder
Melting Point: 104-109°C
Boiling Point: 280-281°C
Density: 1.39 g/cm³
Usage: Widely used in pharmaceuticals and agrochemicals.
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| Attribute | Details |
|---|---|
| Name | 2-Hydroxypyridine |
| CAS Number | 142-08-5 |
| Synonyms | 2-Pyridinol; 2-Pyridone; 2-Pyridyl alcohol; 2-Hydroxy-pyridine; 1H-2-Pyridone; 2(1H)-Pyridone |
| Molecular Formula | C5H5NO |
| Molecular Weight | 95.10 g/mol |
| Appearance | White to pale yellow crystals |
| Melting Point | 105-107°C (lit.) |
| Boiling Point | 323.7±15.0°C at 760 mmHg |
| Density | 1.1±0.1 g/cm³ |
| Flash Point | 181.1±5.3°C |
| Solubility | Soluble in water, slightly soluble in chloroform and alcohol, practically insoluble in ether and benzene |
| Chemical Properties | Acts as a nucleophile and can undergo [4+2] cycloaddition reactions as a diene; it is also a classic substrate for iminol-amide tautomerism. |
| Applications | Used as a catalyst in reactions generating β-oxopropyl carbonates from cyclic carbonate compounds and alcohols, as well as in the aminolysis of polyglutamic acid esters. |
| Safety Information | Sensitive to light; irritant; handle with care and avoid contact with skin and eyes; store under inert gas if possible. |
