Pharmaceutical Materials

2′-Hydroxyacetophenone, also known as ortho-hydroxyacetophenone, is a versatile organic compound with the molecular formula C₈H₈O₂ and a molecular weight of 136.15 g/mol. It is widely utilized in pharmaceuticals, fragrances, and organic synthesis. As a key intermediate, it plays a crucial role in synthesizing drugs such as propafenone (used for cardiac arrhythmias) and various flavoring agents. The compound exhibits a characteristic phenolic odor and is a pale yellow to light brown liquid, with a melting point of 4–6 °C and a boiling point of 213–218 °C. Its reactivity stems from both the hydroxyl and ketone functional groups, enabling diverse chemical transformations. Despite its utility, 2′-hydroxyacetophenone is classified as an irritant (Xi) and requires careful handling to avoid skin and eye contact.

Usage： Intermediate of Proppine Spice additives For organic synthesis.

Packaging and Shipping： 200KG/drum

Storage： Stored in a dry and ventilated warehouse; keep away from sunshine; avoid fire; avoid moisture.

Name	2′-Hydroxyacetophenone
Synonyms	usafke-20 FEMA 3548 USAF ke-20 AKOS 90575 O-ACETOPHENOL 2-ACETOPHENOL o-Acetyl phenol AKOS BBS-00003239 O-HYDROXYACETOPHENONE 2′-HYDROXYACETOPHENONE 2′-Hydroxyacetophenone 1-(2-Hydroxyphenyl)ethanone 1-(2-hydroxyphenyl)-ethanon o-hydroxyphenylmethylketone 1-(3-hydroxyphenyl)ethanone 2-Hydroxyphenyl methyl ketone 2-HYDROXYPHENYL METHYL KETONE
CAS	118-93-4 104809-67-8
EINECS	204-288-0
InChI	InChI=1/C8H8O2/c1-6(9)7-4-2-3-5-8(7)10/h2-5,10H,1H3

Molecular Formula	C8H8O2
Molar Mass	136.15
Density	1.131g/mLat 25°C(lit.)
Melting Point	3-6°C(lit.)
Boling Point	213°C717mm Hg(lit.)
Flash Point	>230°F
JECFA Number	727
Water Solubility	slightly soluble
Solubility	0.2g/l
Vapor Presure	~0.2 mm Hg ( 20 °C)
Vapor Density	4.7 (vs air)
Appearance	Liquid
Color	Clear yellow to brown
BRN	386123
pKa	10.06(at 25℃)
Storage Condition	Store below +30°C.
Explosive Limit	0.98-11.8%(V)
Refractive Index	n20/D 1.558(lit.)
Physical and Chemical Properties	Density 1.131 melting point 4-6°C Boiling Point 213 ° C (717 mmHg) refractive index 1.558-1.56 flash point 112°C water-soluble easily soluble
Use	For the synthesis of pharmaceutical intermediates

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