2-Hydroxy-3-trifluoromethylpyridine
Pharmaceutical Materials 2025-03-02
CAS Number: 22245-83-6
Molecular Formula: C6H4F3NO
Molecular Weight: 163.097 g/mol
Appearance: Brownish yellow solid
Usage: Widely used in organic synthesis, particularly as an intermediate in the production of pharmaceuticals and chemicals.
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| Property | Details |
|---|---|
| Molecular Formula | C6H4F3NO |
| Molecular Weight | 163.10 g/mol |
| CAS Number | 625-95-6 |
| Appearance | White to off-white crystalline solid or powder |
| Purity | Typically ≥98% |
| Melting Point | 104-106 °C |
| Boiling Point | Decomposes before boiling |
| Density | ~1.4 g/cm³ (predicted) |
| Solubility | Soluble in organic solvents such as ethanol, DMSO; slightly soluble in water |
| Applications | Organic synthesis, pharmaceuticals, and agrochemicals |
| Safety Considerations | Handle with care; avoid contact with skin and eyes; store in a cool, dry place away from moisture and strong acids |
| Suppliers | Available from various chemical suppliers globally |
Applications
2-Hydroxy-3-trifluoromethylpyridine is a versatile compound used in organic synthesis, pharmaceuticals, and agrochemicals. Its unique structure, featuring a hydroxyl group and a trifluoromethyl group on the pyridine ring, provides distinct reactivity and physical properties, making it a valuable intermediate in the synthesis of various chemicals.
In organic synthesis, 2-Hydroxy-3-trifluoromethylpyridine serves as a building block for the synthesis of complex molecules, such as pyridine derivatives and heterocyclic compounds. Its hydroxyl group can be functionalized to introduce diverse chemical groups, allowing for the creation of new molecules with tailored properties.
In pharmaceuticals, this compound is utilized in the development of drugs with diverse biological activities. The trifluoromethyl group can enhance the pharmacological activity of drug molecules, contributing to improved therapeutic outcomes.
In agrochemicals, 2-Hydroxy-3-trifluoromethylpyridine finds applications in the synthesis of herbicides and pesticides, offering improved potency and environmental safety. Its solubility in organic solvents facilitates its use in various synthetic methodologies, while its stability under appropriate storage conditions ensures its reliability in research and industrial applications.
