Pharmaceutical Materials

2-Fluorophenol is a crucial intermediate in organic synthesis, widely utilized in pharmaceuticals, agrochemicals, and dye manufacturing. Its structure features a fluorine atom at the ortho position of a phenol ring, enhancing reactivity via electron-withdrawing effects. This compound serves as a precursor for drugs (e.g., Parkinson’s disease therapeutics) and pesticides, enabling selective functionalization through nucleophilic substitution and metal-catalyzed cross-coupling reactions. Industrial synthesis routes include fluorination of phenol derivatives or hydrolysis of 2-fluorobenzene nitro compounds. Its high demand stems from its role in producing fluorinated aromatics, which improve metabolic stability and bioavailability in pharmaceuticals. Due to its flammability and toxicity, it requires careful handling under inert conditions.

Usage： Used as pharmaceutical intermediate and other organic synthetic intermediates.

Packaging and Shipping： 25kg/ drum or as per buyer requirement.

 Storage: Ventilated and dry; separate from alkalis, oxidisers, organic materials and flammable materials.

Name	2-Fluorophenol
Synonyms	2-Florophenol 2-fluoro-pheno 2-Fluorophenol 2-FLUOROPHENOL 2-Hydroxyfluorobenzene 2-FLUOROHYDROXYBENZENE Adjacent fluorine phenol 1-Fluoro-2-hydroxybenzene Fluorophenolmincolorlessliq
CAS	367-12-4
EINECS	206-681-2
InChI	InChI=1/C6H5FO/c7-5-3-1-2-4-6(5)8/h1-4,8H
InChIKey	HFHFGHLXUCOHLN-UHFFFAOYSA-N

Molecular Formula	C6H5FO
Molar Mass	112.1
Density	1.256 g/mL at 25 °C (lit.)
Melting Point	16.1 °C (lit.)
Boling Point	171-172 °C/741 mmHg (lit.)
Flash Point	116°F
Water Solubility	80.72g/L(25 ºC)
Solubility	37.7g/l
Vapor Presure	2.86mmHg at 25°C
Appearance	Transparent liquid
Specific Gravity	1.256
Color	Clear colorless to light yellow-brownish
BRN	1905112
pKa	8.73(at 25℃)
Storage Condition	Inert atmosphere,Room Temperature
Stability	Stable. Flammable. Incompatible with strong oxidizing agents.
Refractive Index	n20/D 1.511(lit.)
MDL	MFCD00002155
Physical and Chemical Properties	Colorless transparent liquid, melting point 16.1 ℃, boiling point 171-172 ℃/741mmHg, Flash Point 46 ℃, specific gravity 1.256, refractive index 1.5140.
Use	Used as pesticide, pharmaceutical and dye intermediates

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