2-Fluorophenol
News 2025-04-07
Product Name: 2-Fluorophenol (2-Fluorophenol; o-Fluorophenol)
CAS Number: 367-12-4
Molecular Formula: C₆H₅FO
Molecular Weight: 112.1 g/mol
Physical Properties:
- Appearance: Colorless to pale yellow-brown liquid
- Melting Point: 16.1°C
- Boiling Point: 171-172°C (741 mmHg)
- Density: 1.256 g/mL (25°C)
- Solubility: Soluble in water (37.7 g/L at 25°C) and organic solvents
- Flash Point: 116°F (46.6°C)
- pKa: 8.73 (at 25°C)
Uses:
- Pharmaceutical Intermediates:
- Serves as a key intermediate in the synthesis of antifungal agents, herbicides, and pesticides.
- Utilized in the development of drug candidates for antimicrobial and anticancer therapies.
- Agrochemicals:
- Employed in the production of fungicides and herbicides due to its halogenated structure, which enhances biological activity and stability.
- Dyes and Pigments:
- Acts as a building block for fluorescent dyes and liquid crystal materials, leveraging its aromatic and fluorinated properties.
- Polymer and Material Science:
- Incorporated into the synthesis of additives for plastics and rubbers, improving thermal stability and mechanical properties.
- Organic Synthesis:
- Used as a reagent in nucleophilic aromatic substitution reactions and cross-coupling reactions (e.g., Suzuki-Miyaura coupling) to introduce fluorine-containing functional groups.
- Life Sciences Research:
- Applied as a biochemical reagent in studies involving protein-ligand interactions and enzyme inhibition.
Safety and Handling:
- Hazards: Flammable, corrosive, and toxic upon inhalation or skin contact.
- Storage: Store in a cool, dry place under an inert atmosphere to prevent degradation.
- Transport: Classified as a hazardous material (UN 1993, Class 3, PG III).
Packaging and Availability:
- Supplied in various package sizes (1 kg, 25 kg, 100 kg, 1 MT) by manufacturers such as Huai’an Chenhui Technology, Weifang Weimeng Chemical, and Nanjing Biomuda Biotechnology.
