2-Fluorobenzoylchloride CAS 393-52-2

The preparation method of ortho fluorobenzoyl chloride includes the following steps: (1) synthesis of ortho fluorotrichlorobenzene: mixing ortho fluorotoluene and triethanol, heating, adding azobis...

Introduction

The preparation method of ortho fluorobenzoyl chloride includes the following steps: (1) synthesis of ortho fluorotrichlorobenzene: mixing ortho fluorotoluene and triethanol, heating, adding azobisisobutyronitrile, and starting to introduce chlorine gas to obtain the intermediate ortho trichlorobenzene; (2) Synthesis of ortho fluorobenzoyl chloride: Under stirring conditions, the ortho fluorotrichlorobenzene obtained in step (1) is heated and maintained at a slight negative pressure. Then, a 0.5% zinc chloride aqueous solution is slowly added dropwise, and the dropwise addition is completed within 3 hours; If the conversion of ortho fluorotrichlorobenzene is not complete, add dropwise zinc chloride aqueous solution until ortho fluorotrichlorobenzene is completely converted, purify by vacuum distillation, collect the 100-105 ℃ fraction, and obtain ortho fluorobenzoyl chloride. The preparation method of ortho fluorobenzoyl chloride has the advantages of fewer steps, high product yield, and high purity.

Name 2-Fluorobenzoyl chloride
Synonyms NSC 88304
2-Fluorobenzoyl
2-Fluorobenzoyl chlo
2-Fluorbenzoylchlorid
2-Fluorobenzoyl chloride
o-Fluorobenzoyl chloride
Orthofluorine benzoyl chloride
o-fluorobenzenecarbonyl chloride
2-Fluorobenzenecarbonyl Chloride
CAS 393-52-2
EINECS 206-887-2
InChI InChI:1S/C7H4ClFO/c8-7(10)5-3-1-2-4-6(5)9/h1-4H
Molecular Formula C7H4ClFO
Molar Mass 158.56
Density 1.328 g/mL at 25 °C (lit.)
Melting Point 4 °C (lit.)
Boling Point 90-92 °C/15 mmHg (lit.)
Flash Point 180°F
Water Solubility Decomposition
Solubility Chloroform (Slightly)
Vapor Presure 8.22E-06mmHg at 25°C
Appearance Liquid
Specific Gravity 1.328
Color Clear colorless to faintly colored
BRN 636864
Storage Condition Inert atmosphere,Room Temperature
Sensitive Lachrymatory
Refractive Index n20/D 1.536(lit.)
Physical and Chemical Properties Colorless liquid. Boiling Point: 90 ℃-92 ℃, Melting Point: 4 ℃, Flash point: 82 ℃, refractive index: 1.5365, specific gravity: 1.328.
Use Used as dye, pesticide, pharmaceutical intermediates

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