2-Fluorobenzoylchloride CAS 393-52-2
Category：Active Pharmaceutical Ingredients
Introduction
The preparation method of ortho fluorobenzoyl chloride includes the following steps: (1) synthesis of ortho fluorotrichlorobenzene: mixing ortho fluorotoluene and triethanol, heating, adding azobisisobutyronitrile, and starting to introduce chlorine gas to obtain the intermediate ortho trichlorobenzene; (2) Synthesis of ortho fluorobenzoyl chloride: Under stirring conditions, the ortho fluorotrichlorobenzene obtained in step (1) is heated and maintained at a slight negative pressure. Then, a 0.5% zinc chloride aqueous solution is slowly added dropwise, and the dropwise addition is completed within 3 hours; If the conversion of ortho fluorotrichlorobenzene is not complete, add dropwise zinc chloride aqueous solution until ortho fluorotrichlorobenzene is completely converted, purify by vacuum distillation, collect the 100-105 ℃ fraction, and obtain ortho fluorobenzoyl chloride. The preparation method of ortho fluorobenzoyl chloride has the advantages of fewer steps, high product yield, and high purity.
| Name | 2-Fluorobenzoyl chloride |
| Synonyms | NSC 88304 2-Fluorobenzoyl 2-Fluorobenzoyl chlo 2-Fluorbenzoylchlorid 2-Fluorobenzoyl chloride o-Fluorobenzoyl chloride Orthofluorine benzoyl chloride o-fluorobenzenecarbonyl chloride 2-Fluorobenzenecarbonyl Chloride |
| CAS | 393-52-2 |
| EINECS | 206-887-2 |
| InChI | InChI:1S/C7H4ClFO/c8-7(10)5-3-1-2-4-6(5)9/h1-4H |
| Molecular Formula | C7H4ClFO |
| Molar Mass | 158.56 |
| Density | 1.328 g/mL at 25 °C (lit.) |
| Melting Point | 4 °C (lit.) |
| Boling Point | 90-92 °C/15 mmHg (lit.) |
| Flash Point | 180°F |
| Water Solubility | Decomposition |
| Solubility | Chloroform (Slightly) |
| Vapor Presure | 8.22E-06mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.328 |
| Color | Clear colorless to faintly colored |
| BRN | 636864 |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Lachrymatory |
| Refractive Index | n20/D 1.536(lit.) |
| Physical and Chemical Properties | Colorless liquid. Boiling Point: 90 ℃-92 ℃, Melting Point: 4 ℃, Flash point: 82 ℃, refractive index: 1.5365, specific gravity: 1.328. |
| Use | Used as dye, pesticide, pharmaceutical intermediates |
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