(2-Fluoro-4- (4-Ethylcyclohexyl) phenyl) boronic acid
Semiconductor Display Materials 2025-03-04
(2-Fluoro-4-(4-Ethylcyclohexyl)phenyl)boronic acid is an organoboron compound featuring a fluorinated phenyl ring substituted with a 4-ethylcyclohexyl group at the para position, and a boronic acid group at the meta position relative to the fluorine atom. This compound is structurally characterized by the combination of a fluorine atom and a bulky cyclohexyl substituent, which influences its electronic properties and steric effects.
Key Properties
| Property | Details |
|---|---|
| IUPAC Name | (2-Fluoro-4-(4-Ethylcyclohexyl)phenyl)boronic acid |
| CAS Number | N/A (Specific CAS number may not be available) |
| Molecular Formula | C₁₄H₁₉BFO₂ (Inferred based on propyl analog) |
| Molecular Weight | 247.11 g/mol (Calculated based on inferred molecular formula) |
| Appearance | White powder (Inferred based on propyl analog) |
| Density | ~1.1 g/cm³ (Slightly lower than propyl analog) |
| Boiling Point | ~375°C (Similar to propyl analog) |
| Refractive Index | N/A (Similar to propyl analog) |
| Flash Point | N/A (Similar to propyl analog) |
| Synthesis Method | Palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura coupling) |
| Applications | Organic synthesis, medicinal chemistry, development of novel pharmaceuticals |
Synthesis
The compound is likely synthesized via palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura coupling. This method involves the reaction of a fluorinated aryl halide with a 4-ethylcyclohexyl-substituted arylboronic acid, facilitated by a palladium catalyst, to construct the biphenyl framework efficiently.
Applications
In organic synthesis, (2-Fluoro-4-(4-Ethylcyclohexyl)phenyl)boronic acid serves as a valuable building block for the preparation of complex molecules, especially those requiring defined stereochemistry and functionality. The fluorinated phenyl structure makes it a promising candidate for the development of novel pharmaceuticals, agrochemicals, and functional materials. The boronic acid moiety can be further transformed into other functional groups, expanding the scope of its applications.
Stability and Storage
The compound is expected to be stable under normal conditions when stored in a cool, dry place, protected from light and moisture. It is recommended to store it under inert gas to prevent oxidation.
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
