2-Cyanobenzyl bromide
Pharmaceutical Materials 2025-03-02
CAS Number: 22115-41-9
Molecular Formula: C8H6BrN
Molecular Weight: 196.04 g/mol
Appearance: White to light yellow crystalline powder
Melting Point: 72-74°C
Boiling Point: 111°C at 1.5 mmHg
Usage: Used as an intermediate in pharmaceutical and chemical synthesis.
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| Attribute | Information |
|---|---|
| Chemical Name | 2-Cyanobenzyl bromide |
| CAS Number | 22115-41-9 |
| Molecular Formula | C8H6BrN |
| Molecular Weight | 196.04 g/mol |
| Appearance | Colorless to pale yellow crystalline solid |
| Melting Point | 72-74 °C |
| Boiling Point | 264.6 °C (at 760 mmHg) |
| Density | Approx. 1.5 g/cm³ |
| Solubility | Soluble in organic solvents |
| Chemical Structure | Benzene ring with a cyano group (-CN) at the 2-position and a bromomethyl group (-CH2Br) at the benzyl position |
| Stability | Stable under normal conditions, but incompatible with strong oxidizing agents and bases |
| Hazard Classification | Irritant, toxic |
| Applications | Used as an intermediate in the synthesis of pharmaceuticals, pesticides, and dyes. Specifically, it serves as a key precursor in the synthesis of impurities of certain oral hypoglycemic drugs. |
| Synthesis Route | Typically synthesized by reacting 2-cyanobenzaldehyde with bromine and hydrogen bromide in the presence of a catalyst. |
| Safety Precautions | Handle with care. Avoid contact with skin, eyes, and clothing. Wear appropriate protective equipment. Store in a cool, dry place, away from incompatible materials. |
