2-Chlorothiophene
Pharmaceutical Materials 2025-03-02
CAS Number: 96-43-5
Molecular Formula: C4H3ClS
Molecular Weight: 118.58 g/mol
Appearance: Colorless liquid
Melting Point: -71.9°C
Boiling Point: 127-129°C
Usage: Widely used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.
| Aspect |
Details |
| Name |
2-Chlorothiophene |
| Common Synonyms |
2-Chlorothiolen, Thienyl chloride (2-position) |
| CAS No. |
5268-17-5 |
| Molecular Formula |
C₄H₃ClS |
| Molecular Weight |
118.59 g/mol |
| Physical Properties |
- Appearance: Colorless to pale yellow liquid
- Boiling Point: 143-145 °C
- Melting Point: -56 °C
- Solubility: Slightly soluble in water; soluble in organic solvents (e.g., ethanol, ether)
- Density: 1.28 g/cm³
|
| Chemical Properties |
- Contains a chlorine atom and a thiophene ring (five-membered heterocycle with sulfur)
- Exhibits electrophilic substitution reactivity due to the electron-rich thiophene ring
- Undergoes nucleophilic substitution at the chlorine position under suitable conditions
- Stable under normal conditions but may react with strong nucleophiles or bases
|
| Applications |
- Used as an intermediate in pharmaceutical synthesis (e.g., antiviral and antifungal agents)
- Employed in agrochemicals as a building block for herbicides and pesticides
- Utilized in organic synthesis for the preparation of polymers and specialty chemicals
|
| Safety Information |
- GHS Hazards: H302 (harmful if swallowed), H315 (causes skin irritation)
- Precautionary Measures: Avoid inhalation and contact with eyes; use PPE
- Storage: Keep in a tightly sealed container in a cool, well-ventilated area
|
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