Pharmaceutical Materials

CAS Number: 96-43-5

Molecular Formula: C4H3ClS

Molecular Weight: 118.58 g/mol

Appearance: Colorless liquid

Melting Point: -71.9°C

Boiling Point: 127-129°C

Usage: Widely used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.

 

Aspect	Details
Name	2-Chlorothiophene
Common Synonyms	2-Chlorothiolen, Thienyl chloride (2-position)
CAS No.	5268-17-5
Molecular Formula	C₄H₃ClS
Molecular Weight	118.59 g/mol
Physical Properties	Appearance: Colorless to pale yellow liquid Boiling Point: 143-145 °C Melting Point: -56 °C Solubility: Slightly soluble in water; soluble in organic solvents (e.g., ethanol, ether) Density: 1.28 g/cm³
Chemical Properties	Contains a chlorine atom and a thiophene ring (five-membered heterocycle with sulfur) Exhibits electrophilic substitution reactivity due to the electron-rich thiophene ring Undergoes nucleophilic substitution at the chlorine position under suitable conditions Stable under normal conditions but may react with strong nucleophiles or bases
Applications	Used as an intermediate in pharmaceutical synthesis (e.g., antiviral and antifungal agents) Employed in agrochemicals as a building block for herbicides and pesticides Utilized in organic synthesis for the preparation of polymers and specialty chemicals
Safety Information	GHS Hazards: H302 (harmful if swallowed), H315 (causes skin irritation) Precautionary Measures: Avoid inhalation and contact with eyes; use PPE Storage: Keep in a tightly sealed container in a cool, well-ventilated area

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