2-Chloropyrimidine
Pharmaceutical Materials 2025-03-02
CAS Number: 1722-12-9
Molecular Formula: C4H3ClN2
Molecular Weight: 114.53 g/mol
Appearance: White to pale yellow crystalline powder
Melting Point: 63-66°C
Boiling Point: 199.2°C at 760 mmHg
Usage: Widely used in organic synthesis and pharmaceutical synthesis.
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| Attribute | Details |
|---|---|
| Chemical Name | 2-Chloropyrimidine |
| Synonyms | 2-Chlor-4.6-diaminopyrimidine (in tautomeric form); Chloropyrimidine; 2-Chlor-1.3-diazine; etc. |
| CAS Number | 1722-12-9 |
| Molecular Formula | C4H3ClN2 |
| Molecular Weight | 114.53 g/mol |
| Appearance | Colorless to light yellow crystalline solid |
| Melting Point | 61-63 °C |
| Boiling Point | 207 °C at 760 mmHg |
| Density | 1.37 g/cm³ at 25 °C |
| Solubility | Soluble in water, ethanol, ether, and chloroform |
| Chemical Properties | Heterocyclic aromatic compound with a chloro group attached to the pyrimidine ring; stable under normal conditions; reacts with various reagents to form derivatives |
| Applications | Used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes; also used in the preparation of heterocyclic compounds and other chemical products |
| Synthesis Method | Can be synthesized by reacting 2.4.6-trichloropyrimidine with ammonia or amines; alternatively, it can be prepared by the chlorination of pyrimidine or its derivatives |
| Stability | Stable under normal conditions; should be stored in a cool, dry place away from heat, flames, and incompatible materials |
| Safety Information | May cause skin and eye irritation; harmful if swallowed or inhaled; may cause respiratory sensitization; wear appropriate protective equipment when handling; refer to the MSDS for detailed safety information and appropriate disposal methods |
