2-Chloro-6-fluorobenzaldehyde CAS No.:387-45-1
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Category：Pharmaceutical Materials Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
2-Chloro-6-fluorobenzaldehyde is a vital intermediate in organic synthesis, widely employed in pharmaceuticals and agrochemicals. Its structure features a chlorine atom and a fluorine atom on a benzene ring, with an aldehyde functional group, enabling diverse reactivity such as nucleophilic addition, condensation, and cross-coupling reactions. This compound is a key precursor for fluoroquinolone antibiotics and low-toxicity fungicides, offering enhanced efficacy compared to non-fluorinated analogs. Industrial synthesis routes include chlorination of 2-fluoro-6-methylbenzaldehyde or fluorination of 2-chlorobenzaldehyde. Due to its air sensitivity and tendency to oxidize, it requires storage under inert conditions. Its high purity (≥99%) and stability make it indispensable in modern chemical manufacturing.
Usage： Used as pharmaceutical intermediate and other organic synthetic intermediates.
Packaging and Shipping： 25kg/ drum or as per buyer requirement.
Storage: Ventilated and dry; separate from alkalis, oxidisers, organic materials and flammable materials.
| Name | 2-Chloro-6-fluorobenzaldehyde |
| Synonyms | AKOS BBS-00003159 LABOTEST-BB LT00942032 2-Chlor-6-fluorbenzaldehyd 2-Chloro-6 Florobenzaldehyde 2-Choro-6-Fluoro Benzaldehyde 2-Chloro-6-fluorobenzaldehyde 4-Chloro-6-fluorobenzaldehyde 2-Fluoro-6-chloro benzaldehyde 2-fluoro-6-chlorobenzene Methylal |
| CAS | 387-45-1 |
| EINECS | 206-860-5 |
| InChI | InChI=1/C7H4ClFO/c8-6-2-1-3-7(9)5(6)4-10/h1-4H |
| Molecular Formula | C7H4ClFO |
| Molar Mass | 158.56 |
| Density | 1.3310 (estimate) |
| Melting Point | 32-35°C(lit.) |
| Boling Point | 92 °C (10 mmHg) |
| Flash Point | 215°F |
| Water Solubility | Insoluble |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| Vapor Presure | 0.272mmHg at 25°C |
| Appearance | White crystal |
| Color | White to yellow |
| BRN | 2245530 |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | Air Sensitive |
| Refractive Index | 1.559 |
| MDL | MFCD00003306 |
| Physical and Chemical Properties | Melting Point 34-39°C boiling point 92 ° C (10 mmHg) flash point 101°C water-soluble Insoluble |
| Use | Mainly used as raw materials for the synthesis of pharmaceutical antibiotics and pesticide plant growth regulators |
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