2-Chloro-5-chloromethylthiazole 

CAS No.: 105827-91-6

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1. Chemical Identification

Property	Specification
IUPAC Name	2-Chloro-5-(chloromethyl)thiazole
Molecular Formula	C₄H₃Cl₂NS
Molecular Weight	168.04 g/mol

Synonyms:
5-Chloromethyl-2-chlorothiazole

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2. Physical Properties

Parameter	Value
Appearance	Colorless to pale yellow liquid
Boiling Point	85-87°C at 15 mmHg
Density	1.45 g/cm³ at 25°C
Refractive Index	1.572 (20°C)
Flash Point	92°C (closed cup)

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3. Chemical Properties

• Reactivity:
  ✓ Electrophilic at chloromethyl position
  ✓ Nucleophilic at thiazole ring positions
• Stability:
  ✓ Moisture-sensitive
  ✓ Light-sensitive

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4. Applications

• Agrochemical Intermediate:
  ✓ Key precursor for neonicotinoid insecticides
  ✓ Thiamethoxam synthesis
• Pharmaceutical Building Block:
  ✓ Thiazole-containing drug development
• Material Science:
  ✓ Functionalized thiazole polymers

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5. Safety Information

Hazard Statements:

• H314: Causes severe skin burns and eye damage
• H335: May cause respiratory irritation
• H411: Toxic to aquatic life with long-lasting effects

Protective Measures:

• P280: Wear chemical-resistant gloves/face protection
• P305+P351+P338: Eye contact rinse procedure
• P310: Immediate medical attention required

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