2-Chloro-5-chloromethylthiazole CAS No.105827-91-6

Agrochemicals 2025-03-02

2-Chloro-5-chloromethylthiazole 

CAS No.: 105827-91-6


1. Chemical Identification

Property Specification
IUPAC Name 2-Chloro-5-(chloromethyl)thiazole
Molecular Formula C₄H₃Cl₂NS
Molecular Weight 168.04 g/mol

Synonyms:
5-Chloromethyl-2-chlorothiazole


2. Physical Properties

Parameter Value
Appearance Colorless to pale yellow liquid
Boiling Point 85-87°C at 15 mmHg
Density 1.45 g/cm³ at 25°C
Refractive Index 1.572 (20°C)
Flash Point 92°C (closed cup)

3. Chemical Properties

  • Reactivity:
    ✓ Electrophilic at chloromethyl position
    ✓ Nucleophilic at thiazole ring positions
  • Stability:
    ✓ Moisture-sensitive
    ✓ Light-sensitive

4. Applications

  • Agrochemical Intermediate:
    ✓ Key precursor for neonicotinoid insecticides
    ✓ Thiamethoxam synthesis
  • Pharmaceutical Building Block:
    ✓ Thiazole-containing drug development
  • Material Science:
    ✓ Functionalized thiazole polymers

5. Safety Information

Hazard Statements:

  • H314: Causes severe skin burns and eye damage
  • H335: May cause respiratory irritation
  • H411: Toxic to aquatic life with long-lasting effects

Protective Measures:

  • P280: Wear chemical-resistant gloves/face protection
  • P305+P351+P338: Eye contact rinse procedure
  • P310: Immediate medical attention required

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