2-Chloro-5-chloromethylthiazole CAS No.105827-91-6
Agrochemicals 2025-03-02
2-Chloro-5-chloromethylthiazole
CAS No.: 105827-91-6
1. Chemical Identification
| Property | Specification |
|---|---|
| IUPAC Name | 2-Chloro-5-(chloromethyl)thiazole |
| Molecular Formula | C₄H₃Cl₂NS |
| Molecular Weight | 168.04 g/mol |
Synonyms:
5-Chloromethyl-2-chlorothiazole
2. Physical Properties
| Parameter | Value |
|---|---|
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 85-87°C at 15 mmHg |
| Density | 1.45 g/cm³ at 25°C |
| Refractive Index | 1.572 (20°C) |
| Flash Point | 92°C (closed cup) |
3. Chemical Properties
- Reactivity:
✓ Electrophilic at chloromethyl position
✓ Nucleophilic at thiazole ring positions - Stability:
✓ Moisture-sensitive
✓ Light-sensitive
4. Applications
- Agrochemical Intermediate:
✓ Key precursor for neonicotinoid insecticides
✓ Thiamethoxam synthesis - Pharmaceutical Building Block:
✓ Thiazole-containing drug development - Material Science:
✓ Functionalized thiazole polymers
5. Safety Information
Hazard Statements:
- H314: Causes severe skin burns and eye damage
- H335: May cause respiratory irritation
- H411: Toxic to aquatic life with long-lasting effects
Protective Measures:
- P280: Wear chemical-resistant gloves/face protection
- P305+P351+P338: Eye contact rinse procedure
- P310: Immediate medical attention required
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