2-Chloro-4,5-difluorobenzoic acid CAS No.:110877-64-0
Pharmaceutical Materials 2025-03-03
2-Chloro-4,5-difluorobenzoic acid (CDFBA) is a crucial intermediate in pharmaceutical and agrochemical synthesis, primarily utilized in the production of novel fluoroquinolone antibiotics and cardiovascular drugs. Its molecular structure features a chlorine atom and two fluorine atoms substituting the benzene ring, imparting unique reactivity and stability. CDFBA is synthesized via chlorination, acylation, and oxidation of fluorinated precursors, with methods including chloroacetyl chloride and tetrachloromethane acylation routes. Its high purity (≥98%) and solubility in organic solvents make it valuable for drug development. As a key building block, CDFBA enhances the efficacy and pharmacokinetic properties of active pharmaceutical ingredients (APIs), supporting advancements in therapeutic innovation.
Usage： Used as pharmaceutical intermediate and other organic synthetic intermediates.
Packaging and Shipping： 25kg/ drum or as per buyer requirement.
Storage: Ventilated and dry; separate from alkalis, oxidisers, organic materials and flammable materials.
| Name | 2-Chloro-4,5-difluorobenzoic acid |
| Synonyms | 405-380-5 110877-64-0 QVR BG DF EF TIMTEC-BB SBB003616 RARECHEM AL BO 1000 2-chloro-4,5-difluorobenzoate 2-chloro-4,5-difluorophenyl acid 2-CHLORO-4,5-DIFLUOROBENZOIC ACID 2-Chloro-4,5-difluorobenzoic acid 2-Chloride-4,5-Difluoride Benzoic Acids |
| CAS | 110877-64-0 |
| EINECS | 405-380-5 |
| InChI | InChI=1/C7H3ClF2O2/c8-4-2-6(10)5(9)1-3(4)7(11)12/h1-2H,(H,11,12)/p-1 |
| Molecular Formula | C7H3ClF2O2 |
| Molar Mass | 192.55 |
| Density | 1.4821 (estimate) |
| Melting Point | 103-106 °C (lit.) |
| Boling Point | 258 °C |
| Flash Point | 257-259°C |
| Water Solubility | 5.0 g/L (20 ºC) |
| Vapor Presure | 0.00273mmHg at 25°C |
| Appearance | White powder |
| Color | White |
| BRN | 4247522 |
| pKa | 2.50±0.25(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
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