2-Chloro-3-pyridinecarboxaldehyde
Biomedicine 2025-03-04
CAS.No：36404-88-3
Appearance: white solid powder
Molecular Formula :C6H6ClNO
Purity:≥99.5%
Molecular weight:143.57
Capacity:20T/M
Application:Pharmaceutical intermediates
Basic Information of 2-Chloro-3-Pyridinecarboxaldehyde
| Aspect | Details |
|---|---|
| Chemical Name | 2-Chloro-3-Pyridinecarboxaldehyde (2-Chloronicotinaldehyde) |
| CAS Number | 36404-88-3 |
| Molecular Formula | C₆H₄ClNO |
| Molecular Weight | 141.56 g/mol |
| Appearance | White to off-white powder |
| Melting Point | 50-54°C (lit.) |
| Boiling Point | 119°C (30 Torr) |
| Density | 1.332±0.06 g/cm³ (Predicted) |
| Solubility | Soluble in chloroform, DMSO, methanol |
| Storage Conditions | Store in a cool, dark place under inert gas (nitrogen or argon) |
| pKa | -1.36±0.10 (Predicted) |
Additional Information on 2-Chloro-3-Pyridinecarboxaldehyde
| Aspect | Details |
|---|---|
| Synonyms | 2-Chloronicotinaldehyde, Chloro-2-formyl-3-pyridine, 2-Chloro-3-formylpyridine |
| Applications | – Pharmaceutical Intermediate: Used as a key intermediate in the synthesis of various pharmaceutical compounds, including kinase inhibitors.<br>- Organic Synthesis: Used in the preparation of 5-azaindoles by the Hemetsberger-Knittel reaction.<br>- Agrochemicals: Used as an intermediate in the synthesis of agrochemicals. |
| Safety Information | – Hazard Statements: H301 (Toxic if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation).<br>- Precautionary Statements: P261 (Avoid breathing dust/fume/gas/mist/vapours/spray), P264 (Wash skin thoroughly after handling), P280 (Wear protective gloves/eye protection/face protection), P301+P312 (IF SWALLOWED: Call a POISON CENTER/doctor/… if you feel unwell), P302+P352 (IF ON SKIN: Wash with plenty of soap and water).<br>- Storage: Store in a cool, dry place under inert gas. |
| Packaging and Price | – 1g: $20 (TCI America), $40.10 (Sigma-Aldrich).<br>- 5g: $80 (TCI America), $71.10 (Sigma-Aldrich). |
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