Pharmaceutical Materials

2-Butyl-4-chloro-5-formylimidazole is a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly losartan, a widely prescribed antihypertensive drug. Structurally, it is a substituted imidazole derivative with a butyl group, a chlorine atom, and a formyl moiety, contributing to its reactivity in pharmaceutical chemistry. Its synthesis typically involves condensation reactions using precursors like pentamidine hydrochloride and glyoxal, followed by chlorination and formylation steps. This compound exhibits high purity (≥99%) and is commercially available in various forms, including 25 kg paper drums, ensuring scalability for industrial applications. Beyond pharmaceuticals, its role in life science research underscores its utility as a biochemical reagent, facilitating studies on enzyme inhibition and molecular interactions.

Usage： Intermediate of antihypertensive drug Losartan. 2. Sartan intermediates.

Packaging and Shipping： 25KG/drum  Storage; Stored in a dry and ventilated warehouse; keep away from sunshine; avoid fire; avoid moisture.

Chemical Name: 2-Butyl-4-chloro-5-formylimidazole

Assay:99.78%min

Appearance: yellow to light yellow crystalline powder

 

Name	2-Butyl-5-chloro-1H-imidazole-4-Carboxaldehyde
Synonyms	BCFI 2-Butyl-4-Chloro-5-formylimidazloe 2-Butyl-4-chloro-5-formylimidazole(BCFI) 2-Butyl-5-Chloroimidazole-4-Carboxaldehyde 2-Butyl-4-Chloro-1H-imidazo-5-Carboxaldehyde 2-Butyl-5-Chloro-1H-Imidazole-4-Carbaldehyde 2-Butyl-5-chloro-1H-imidazole-4-Carboxaldehyde (2-n-Butyl-5-Chloro-imidazole-4-yl)-Carboxaldehyde
CAS	83857-96-9
EINECS	410-260-0
InChI	InChI=1/C8H11ClN2O/c1-2-3-4-7-10-6(5-12)8(9)11-7/h5H,2-4H2,1H3,(H,10,11)
InChIKey	JLVIHQCWASNXCK-UHFFFAOYSA-N

Molecular Formula	C8H11ClN2O
Molar Mass	186.64
Density	1.24
Melting Point	97-100℃
Water Solubility	slightly soluble
Appearance	Shape neat, color Pale Yellow to Brown
pKa	8.87±0.10(Predicted)
Storage Condition	Inert atmosphere,2-8°C
MDL	MFCD01934396
Physical and Chemical Properties	EPA Chemical Information 2-Butyl-5-chloroimidazole-4-carbaldehyde (83857-96-9)
Use	Use antihypertensive drug losartan intermediate. Sartan intermediates.

Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.

If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.