2-Bromothiophene
Pharmaceutical Materials 2025-03-02
CAS Number: 1003-09-4
Molecular Formula: C4H3BrS
Molecular Weight: 163.04 g/mol
Appearance: Colorless to slightly brownish liquid
Melting Point: -10 °C
Boiling Point: 149-151 °C
Density: 1.684 g/mL at 25 °C
Usage: Used as an intermediate in pharmaceutical and organic synthesis.
| Aspect | Details |
|---|---|
| Name | 2-Bromothiophene |
| CAS Number | 615-37-0 |
| Chemical Formula | C₄H₃BrS |
| Molecular Weight | 163.04 g/mol |
| Physical Appearance | Colorless to pale yellow liquid |
| Melting Point | -39°C |
| Boiling Point | 161-163°C |
| Density | 1.61 g/cm³ at 20°C |
| Reactivity | Actively participates in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi). Susceptible to nucleophilic substitution. |
| Solubility | Insoluble in water; soluble in organic solvents (e.g., ethanol, ether, chloroform). |
| Applications | – Organic Synthesis: Key intermediate in the preparation of thiophene-based polymers, pharmaceuticals, and agrochemicals. |
| – Materials Science: Used to functionalize conductive polymers for OLEDs, organic solar cells, and molecular electronics. | |
| Safety Information | – Hazards: Toxic if ingested; causes skin and eye irritation. |
| – Handling: Use PPE (gloves, goggles) in a well-ventilated area. | |
| Storage Conditions | Store in a cool, dry, and tightly sealed container away from light and heat. |
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