2-Bromoacetophenone
Chemical Additives 2025-03-18
2-Bromoacetophenone Technical Specification
| Category | Specifications |
|---|---|
| Chemical Name | 2-Bromoacetophenone |
| Synonyms | Phenacyl bromide; α-Bromoacetophenone |
| CAS Number | 70-11-1 |
| Molecular Formula | C₈H₇BrO |
| Molecular Weight | 199.05 g/mol |
| Appearance | White to pale yellow crystalline solid |
| Melting Point | 48-51°C |
| Boiling Point | 135°C (15 mmHg) |
| Density | 1.647 g/cm³ (20°C) |
| Solubility | Soluble in ethanol, ether; insoluble in water |
Chemical Properties
| Property | Characteristics |
|---|---|
| Reactivity | Strong lachrymator; alkylating agent |
| Stability | Sensitive to light and moisture |
| Decomposition | Releases HBr when heated |
| Characteristic Reactions | Forms acetophenone derivatives via substitution |
Synthesis Methods
| Method | Description |
|---|---|
| Bromination | Direct bromination of acetophenone |
| Oxidation | From styrene derivatives |
Applications
| Industry | Use |
|---|---|
| Organic Synthesis | Precursor for pharmaceuticals |
| Chemical Research | Building block for heterocyclic compounds |
| Specialty Chemicals | Intermediate for fragrances and dyes |
Safety & Handling
| Parameter | Value/Requirement |
|---|---|
| OSHA PEL | Not established |
| LD50 (oral, rat) | 150 mg/kg (estimated) |
| Skin/Eye Effects | Severe irritant |
| Storage Conditions | Cool, dry, dark place in airtight container |
| Personal Protection | Gloves, goggles, respirator required |
Regulatory Status
| Regulation | Status |
|---|---|
| Controlled Substances | Restricted in some jurisdictions |
| EPA Classification | Not listed as priority pollutant |
| EU REACH | Registered substance |
Note: This compound is classified as a lachrymator (tear gas agent) and should be handled with extreme caution in well-ventilated areas using proper personal protective equipment. Its use is strictly regulated in many countries.
