2-Bromo-4-fluorophenol
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Category：Pharmaceutical Materials Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
CAS.No：496-69-5
Appearance: white solid powder
Molecular Formula :C6H4BrFO
Molecular weight:191
Capacity:20T/month
Application:Pharmaceutical intermediates
| Property | Details |
|---|---|
| Molecular Formula | C6H4BrFO |
| Molecular Weight | 186.99 g/mol |
| CAS Number | 394-40-7 |
| Appearance | White to off-white crystalline solid or powder |
| Purity | Typically ≥98% |
| Melting Point | 49-52 °C |
| Boiling Point | 215-217 °C (at 760 mmHg) |
| Density | 1.84 g/cm³ |
| Solubility | Soluble in organic solvents such as ethanol, ether, and DMSO; slightly soluble in water |
| Applications | Organic synthesis, pharmaceuticals, agrochemicals, and materials science |
| Safety Considerations | Handle with care; avoid contact with skin and eyes; store in a cool, dry place away from heat and open flames |
| Suppliers | Available from various chemical suppliers globally |
Applications
2-Bromo-4-fluorophenol is a valuable compound in organic synthesis, particularly in the production of brominated and fluorinated compounds. Its bromine and fluorine substituents provide unique reactivity and physical properties, making it a useful intermediate in the synthesis of various chemicals.
In pharmaceuticals, 2-Bromo-4-fluorophenol is utilized in the development of drugs with enhanced biological activity and specificity. The bromine atom can be used in cross-coupling reactions to introduce diverse functional groups, while the fluorine atom can modulate the lipophilicity and metabolic stability of drug molecules.
In agrochemicals, this compound serves as a building block for the synthesis of herbicides and pesticides, offering improved potency and environmental safety. Additionally, 2-Bromo-4-fluorophenol finds applications in materials science, where its brominated and fluorinated structure can be exploited to create polymers and materials with tailored properties.
Its solubility in organic solvents facilitates its use in various synthetic methodologies, while its stability under appropriate storage conditions ensures its reliability in research and industrial applications.
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