2-Bromo-4′-fluoroacetophenone
Pharmaceutical Materials 2025-03-02
CAS Number: 403-29-2
Molecular Formula: C8H6BrFO
Molecular Weight: 217.04 g/mol
Appearance: White to off-white powder or crystalline solid
Melting Point: 47-49°C
Boiling Point: 150°C (12 mmHg)
Usage: Used as an intermediate in pharmaceutical and chemical syntheses.
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| Attribute | Details |
|---|---|
| Name | 2-Bromo-4′-fluoroacetophenone |
| Other Names | 1-(4-Fluorophenyl)-2-bromoethanone; 4′-Fluoro-2-bromoacetophenone; 2-Bromo-1-(4-fluorophenyl)ethanone |
| CAS Number | 455-69-4 |
| Molecular Formula | C8H6BrFO |
| Molecular Weight | 217.04 g/mol |
| Appearance | Colorless to pale yellow liquid at room temperature |
| Physical Properties | Density: 1.5±0.1 g/cm³; Melting Point: 28-30°C; Boiling Point: 242.4±20.0°C at 760 mmHg; Flash Point: 104.7±22.6°C; Refractive Index: 1.526-1.528; Vapor Pressure: 0.0±1.0 mmHg at 25°C |
| Chemical Properties | Stable under normal conditions. Reacts with nucleophiles at the bromine and carbonyl groups. Can undergo halogen exchange reactions. The fluoro substituent enhances the reactivity of the aromatic ring towards electrophilic substitution. |
| Applications | Used as an intermediate in the synthesis of organic compounds, particularly in the pharmaceutical and agrochemical industries. It serves as a precursor for the preparation of various brominated and fluorinated aromatic derivatives. |
| Toxicological Properties | May be harmful if swallowed or inhaled. Causes skin and eye irritation. May cause respiratory tract irritation. Handle with care and avoid prolonged exposure. |
| Safety Information | Store in a cool, dry place away from heat, sparks, and open flames. Keep away from incompatible materials. Wear appropriate protective clothing, gloves, and eye protection when handling. Follow relevant safety regulations and guidelines. |
