2-Bromo-3-methylthiophene
Pharmaceutical Materials 2025-03-02
CAS Number: 14282-76-9
Molecular Formula: C5H5BrS
Molecular Weight: 177.06 g/mol
Appearance: Colorless to pale yellow liquid
Boiling Point: 173-177.3°C
Density: 1.572-1.6±0.1 g/mL or g/cm3
Usage: Used as an intermediate in pharmaceutical and material science applications.
| Aspect |
Details |
| Name |
2-Bromo-3-methylthiophene |
| Common Synonyms |
3-Methyl-2-bromothiophene, 2-Bromothiophen-3-methyl |
| CAS No. |
5295-99-8 |
| Molecular Formula |
C₅H₅BrS |
| Molecular Weight |
177.06 g/mol |
| Physical Properties |
- Appearance: Colorless to pale yellow liquid
- Boiling Point: 162-164 °C
- Melting Point: -52 °C
- Solubility: Insoluble in water; soluble in organic solvents (e.g., ethanol, ether)
- Density: 1.55 g/cm³
|
| Chemical Properties |
- Contains a bromine atom and a methyl group (-CH₃) on a thiophene ring (five-membered heterocycle with sulfur)
- Exhibits electrophilic substitution reactivity due to the electron-rich nature of the thiophene ring
- Undergoes nucleophilic substitution at the bromine position under suitable conditions
- Stable under normal conditions but may react with strong nucleophiles or bases
|
| Applications |
- Used as an intermediate in pharmaceutical synthesis (e.g., antiviral and antifungal agents)
- Employed in agrochemicals as a building block for herbicides and pesticides
- Utilized in organic synthesis for the preparation of polymers and specialty chemicals
|
| Safety Information |
- GHS Hazards: H302 (harmful if swallowed), H315 (causes skin irritation), H226 (flammable liquid and vapor)
- Precautionary Measures: Avoid inhalation and contact with eyes; use PPE
- Storage: Keep in a tightly sealed container in a cool, well-ventilated area
|
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
