Active Pharmaceutical Ingredients

Catalog ID80020224

CAS NO.59-97-2

Purity 99%

MDL NumberMFCD00012693

EINEC200-447-3

Molecular formula C10H12N2.HCl

Molecular weight 196.72

Melting point: 172~176°C

Category	Information
Chemical Properties	– Molecular Formula: C₁₀H₁₃ClN₂<br>- Molecular Weight: 196.68 g/mol
Physical Properties	– Appearance: White crystalline solid.<br>- Melting Point: 172-176°C.<br>- Solubility: Soluble in water.
Mechanism of Action	– Acts as a non-selective and competitive α-adrenergic receptor antagonist.<br>- Exhibits vasodilatory effects, particularly in pulmonary circulation.
Clinical Uses	– Used as a pulmonary vasodilator in neonates with persistent pulmonary hypertension (PPHN) to reduce pulmonary vascular resistance.<br>- Investigated for other cardiovascular applications.
Storage Conditions	Store at room temperature in an inert atmosphere.
CAS Number	59-97-2
Synonyms	– Tolazoline HCl.<br>- 2-Benzyl-2-imidazoline hydrochloride

 Names and Identifiers

Name	Tolazoline hydrochloride
Synonyms	Tolazoline HCl TIMTEC-BB SBB000360 2-BENZYL-2-IMIDAZOLINE Tolazoline hydrochloride BENZIDAZOL HYDROCHLORIDE BENZAZOLINE HYDROCHLORIDE 2-BENZYL-4,5-IMIDAZOLINE HCL 2-BENZYL-2-IMIDAZOLINE CHLORHYDRATE 2-BENZYL-2-IMIDAZOLINE HYDROCHLORIDE 2-BENZYL-2-IMINAZOLINE HYDROCHLORIDE 2-Benzyl-2-imidazoline hydrochloride
CAS	59-97-2
EINECS	200-447-3
InChI	InChI=1/C10H12N2.ClH/c1-2-4-9(5-3-1)8-10-11-6-7-12-10;/h1-5H,6-8H2,(H,11,12);1H

59-97-2 – Physico-chemical Properties

Molecular Formula	C10H13ClN2
Molar Mass	196.68
Melting Point	172-176 °C
Boling Point	338.2°C at 760 mmHg
Flash Point	158.3°C
Solubility	DMSO (Slightly, Heated), Methanol (Slightly)
Vapor Presure	0.000196mmHg at 25°C
Appearance	Crystalline Powder
Color	White to almost white
Merck	14,9506
Storage Condition	Inert atmosphere,Room Temperature
Stability	Hygroscopic
Sensitive	Hygroscopic
MDL	MFCD00012693
Use	Used as vasodilator
In vitro study	Tolazoline is a pulmonary vasodilator used to attenuate pulmonary vascular resistance (PVR) in neonates with persistent pulmonary hypertension (PPHN). Tolazoline has moderate alpha-adrenergic blocking activity and histamine agonist activity. Tolazoline is commonly used to reduce pulmonary artery pressure and vascular resistance. For all the spasmogenic drugs investigated, Tolazoline did not have a broad range of effects as did SNP. However, in the human radial artery, it may be effective in counteracting alpha-adrenergic receptor-mediated vasospasm.

59-97-2 – Risk and Safety

Hazard Symbols	Xn – Harmful
Risk Codes	22 – Harmful if swallowed
Safety Description	22 – Do not breathe dust.
UN IDs	2811
TSCA	Yes
HS Code	29332900
Toxicity	LD50 orl-rat: 1200 mg/kg NIIRDN 6,511,82

Tolazolin hydrochloride tablets

This product shall contain tolazoline hydrochloride (C10H12N2 • HCl) in an amount of 93.0% to 107.0% of the labeled amount.

---

trait

This product is a sugar-coated tablet, which is white after removing the coating.

---

identification

Take 8 tablets of this product, grind, extract with ethanol for 3 times, 10ml each time, heat, filter, combine filtrate to dry, add water 10ml, dissolve, filter, filtrate to dry, the following tests were performed for residual ulcers.

1. about 10mg of the residue was taken, and 1 ml of water was added to dissolve tolazoline hydrochloride, and several drops of a test solution of ammonium chromate thiocyanate were added to produce a pink precipitate.
2. the aqueous solution of the residue showed the reaction of chloride identification (1) (General 0301).

---

examination

should be in accordance with the relevant provisions under The tablet item (General rule 0101).

---

Content determination

• measured by high performance liquid chromatography (General 0512).
• chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica as filler; Methanol-0.068% phosphoric acid solution [(50:50), the pH value was adjusted to 3.0 with ammonia solution. The detection wavelength was 230nm. The number of theoretical plates shall not be less than 1500 based on the calculation of tazolin peak.
• determination of 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 50mg equivalent to tolazoline hydrochloride), put in a 100ml measuring flask, add an appropriate amount of mobile phase, ultrasonic dissolution of tolazoline hydrochloride, dilute to scale with mobile phase, shake well, filter, Take 5ml of continued filtrate precisely, put it in 50ml measuring flask, dilute to scale with mobile phase, shake well, accurately measure 20ul, inject human liquid chromatograph, record the chromatogram; Take another reference substance of tolazoline hydrochloride, the mobile phase was added to dissolve and quantitatively dilute to prepare a solution containing about 50ug per 1 ml, which was determined by the same method. According to the external standard method to calculate the peak area, that is.

---

category storage

Same as tolazoline hydrochloride.

---

specification

25mg

Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.

If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.